A major development in cardiovascular disease research is the finding that oxidation reactions play a central role in atherogenesis and that in epidemiological studies cardiovascular disease is associated with low plasma concentrations of ascorbate, tocopherol and ß-carotene.
A wealth of evidence suggests that oxidative modification of apolipoprotein B100 plays a key role in LDL recognition and that LDL uptake by scavenger receptors in macrophages leads to foam cell formation and atheroschlerotic plaques.
Apolipoprotein B100 can be altered by reactive products of lipid peroxidation that causes a net decrease in positive charge, a modification that leads to its recognition by the scavenger receptors. The beneficial effects of dietary Antioxidants is also strengthened by animal and biochemical studies.
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