Tuesday, February 12, 2008

Biological Theories

Wear-and-Tear theory
Aging associated changes are the result of chance damage accumulating over time.

Accumulative-Waste Theory
The buildup in cells of waste products that presumably interferes with metabolism.

Autoimmune Theory
Aging results from gradual decline of the body’s autoimmune system.

Cross-Linkage Theory
Aging results from accumulation of cross-linked compounds interfering with normal cell function.

Free-Radical Theory
Free radicals (unstable and highly reactive organic molecules) cause cell damage that results in symptoms we associate with Aging

Cellular Theory
Aging can be explained by structural and functional changes in the cells of an organism.

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Theories of Aging

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Activity Theory

The more active people are the more likely they will be happy.

Continuity Theory

With aging people will tend to maintain the same habits, personalities, and life style that they have developed in earlier years.

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Effects of Aging on Health

Cognitive Effects
Beginning in the thirties is point in the aging process when it is typical to experience cognitive declines. However it is possible to maintain normal cognitive function into old age. Many elderly have memories as sharp or even sharper than their younger counterparts. Semantic or general knowledge memory including vocabulary and definitions remain steady or even increase.

Emotional Effects
Aging typically produces and improvement in emotional intelligence. This is because with age we typically are better able to manage and regulate our emotions. The exception is usually related to health and wellness deficiencies, disease states, or prolonged stress.

Successful Ageing
The Golden Years have been termed "successful ageing" as early as the 1950s and was popularized in the late 80s. The terminology has sparked a debate as to what is “normal ageing" which would have a high risk of illness and "successful ageing" with low risk of disability and high cognitive and physical functioning.

Successful ageing would consist of three components:
1. Low probability of disease or disability

2. High mental and physical function capacity

3. Active engagement with life Alternatively, terms such as "healthy ageing," "optimal ageing" have been proposed.

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The Ultimate Anti-aging Treatment

To facilitate anti aging requires understanding aging. With this knowledge making the changes in life style and diet that can enhance the anti aging process.

Aging
In health care, Ageing or aging in the human body refers to the deterioration of the body the longer we live.

There are social, cognitive, cultural, and economic effects that result from and are effects of Aging. These can affect the way we live our lives, the quality of life we have and the way society views us. One of the ways we care for aging is anti aging treatments.

The Aging population is an important issue in many nations, especially those North of the equator. Thus, age has in influence on the functioning of the society we live in.

In science and biology, Aging is divided into cellular and organism Aging.

The Aging of an organism is is often noted by the declining ability to respond to stress, increased imbalanced homeostasis and increased risk of disease. Some researchers are treating aging as disease. As such, it is considered treatable.

Diet has been shown to play a large role in the anti aging promotion. Dietary intake is considered in a number of ways including nutrient intake, quantity of intake and toxic exposure.

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The Ear Nose Throat Eyes Connection

Glutathione plays an important role in our ear nose throat eyes (ENT) health.

The primary way everything enters our body both good and bad is through the ear nose throat eyes. Actually our eyes are a secondary portal of entry.

The things entering can be good such as breathing, sound and food. It can also be potentially damaging to the body. These include toxins, bacteria's, viruses, and carcinogens. It would only seem natural that the human body would have a defense systems to protect the points of entry.

The good news...it does. It is called the immune system. It is a formidable military force. The strongest front line defense is the marine like tripeptide glutathione. It is not only in each cell, it is in the respiratory tract lining fluid (RTLF). Glutathione is the main antioxidant in this fluid.

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The Upper Respiratory Tract

It depletes with age

The weakest point of the human body would be the place of greatest risk of attack by infection and toxins. Glutathione is the primary defense for the nose and throat.

General Otolaryngology
LaryngitisParotitis (inflammation of the parotid gland)
Pharyngitis (inflammation of the pharynx producing symptoms similar to tonsillitis)
Sleep apneaSnoringTonsillitis (inflammation of tonsils producing pain)
odynophagia (painful swallowing fever etc)
HyperthyroidismThyroid cancer
Sore throat
Strep throat
Esophageal cancer

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The Optimum Level of Antioxidants

The epidemiological evidence and the guidelines of the National Cancer Institute and the National Research Council/National Academy of Sciences suggest that at least two fruits and three vegetables per day is a desirable intake.

Since ascorbate, tocopherol, and ß-carotene supplements are inexpensive and high doses are remarkably non-toxic, there is a school that believes that supplements, in addition to a diet containing recommended levels of fruits and vegetables, are desirable.

There is suggestive, but inadequate epidemiological and biochemical evidence bearing on the question. What is clear is that fruits and vegetables contain many necessary micronutrients in addition to antioxidants, some of which also can prevent mutations. Folic acid, for example, is required for the synthesis of the nucleotides in DNA.

Inadequate intake has been shown to cause chromosome breaks and increased cancer and birth defects. Folate deficiency may be a risk factor for myocardial infarction as well. Niacin is required for making poly (ADP-ribose), a component of DNA repair. Other micronutrients are also likely to be part of our defense systems.

The U.S. Recommended Daily Allowances (RDAs) for ascorbate and tocopherol intake--there is no guideline for [[beta]]-carotene independent of its provitamin A activity--are not adequate for several reasons:

1) The amount recommended, e.g., 60 mg/day for ascorbate, is primarily for avoiding an observable deficiency syndrome, e.g., scurvy, and is not necessarily the amount for optimum lifetime health, which is usually not known.

2) A recommended blood level of each antioxidant, e.g., 60 uM ascorbate, would be a more desirable standard. People vary considerably in the intake required to keep their blood level adequate. A smoker, for example, needs to take in several times as much ascorbate as a non-smoker to keep the blood level the same.

Infections may also cause an oxidative stress that leads to antioxidant depletion by activating phagocytic cells. The observation that antioxidant inadequacy is associated with oxidative damage to DNA of the germ line as well as somatic cells, emphasizes the urgency of defining adequate blood levels.

Since only 9% of Americans, and fewer in most other countries, are eating five fruits and vegetables per day, there is a great opportunity to improve health by increasing consumption.

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Oxidant stress, Birth defects, and Childhood Cancer

Oxidative lesions in sperm DNA are increased 250% when levels of dietary ascorbate is insufficient to keep seminal fluid ascorbate to an adequate level. A sizable percentage of the U.S. population ingest inadequate levels of dietary ascorbate, particularly single males, the poor, and smokers. The oxidants in cigarette smoke deplete the antioxidants in plasma. Smokers must eat two to three times more ascorbate than non-smokers to achieve the same level of ascorbate in blood, but they rarely do.

In a comparison of sperm from smokers and nonsmokers Viczian found that the number of sperm and the percent of mobile sperm decrease significantly in smokers, and this decrease is dependent on the dose and duration of smoking.

Paternal smoking, in particular, appears to increase the risk of birth defects and childhood cancer in their offspring. One expects, and finds, a much larger contribution to the germ line mutation rate from the father than the mother, age of the father being an important risk factor. Thus, inadequate diets (and smoking) of fathers appear to result not only in damage to their own DNA but to the DNA of their sperm, an effect that may reverberate down future generations.

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