Antioxidant:
Antioxidant is a substance that neutralizes destructive free radicals; some are manufactured by the metabolic processes of the body, others are derived from foods, the air we breath, exercise, stress and disease.GSH is the most powerful Antioxidant occurring naturally in the cells of the body. Through its significant reducing power, GSH also makes major contributions to the recycling of other Antioxidant that have become oxidized. Healthy cells homeostatically oppose free radicals through the use of Antioxidant, of which GSH plays a significant role. The effectiveness of other Antioxidant like vitamins C and E depends on the availability of GSH.
Help Prevent Disease:
Oxidative related diseases: accelerated aging, cell destruction, causes damage to DNA cellular patterns which leads to cancer, arteriosclerosis, coronary artery disease, Parkinson’s disease, diseases of the immune system, diabetes, cataract formation, Alzheimer’s, macular degeneration, COPD, allergy/asthma, stroke.
Detoxification:
GSH also plays a main role in detoxification..primarily in Phase II Liver detox. It "binds" to many toxins by its sulfur molecules and aids in forming a complex which the body then rids itself of.
Immune System Support:
When the immune system responds to an invader, it releases a blitz of free radicals to aid in the offensive agent's demise. This could create damage to local tissue and your body, but GSH rallies around the area to quench the free radicals that are produced in excess.
Protection from Radiation:
A recent research article published in the journal Radiology states that “radiation from a single whole-body scan is equal to that from 100 mammograms and is similar to that received by survivors of the atomic bombings of Hiroshima and Nagasaki, Japan – about 1 mile from the explosions – according to radiation biologist, David J. Brenner of Columbia University. The radiation from one scan is enough to produce a tumor in one out of 1200 people, and for those who have annual scans the risk increases to one tumor in every 50 people. With inadequate intracellular GSH the risk is greatly increased.
Showing posts with label strokes. Show all posts
Showing posts with label strokes. Show all posts
Friday, January 18, 2008
Thursday, January 10, 2008
Glutathione and Cardiovascular Disease
Researchers studied the association between fasting plasma total Glutathione levels and cardiovascular disease among 134 cardiovascular disease cases and 435 healthy control subjects.
3 Mean totalGlutathione concentrations were lower in all cardiovascular disease cases than in control subjects. Among subgroups of subjects with different types of cardiovascular disease, both the cerebral infarction cases and cerebral hemorrhage cases had significantly lower Glutathione levels than the corresponding control groups.
After adjustment for other confounding factors, the risk of cardiovascular disease was significantly lower in the subjects with the highest Glutathione levels compared to the subjects with the lowest levels. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage.
According to the study authors, “These findings suggest that reduced plasma total Glutathione levels are a risk factor for CVD, especially for cerebral small vessel disease.”Australian researchers established a similar link between Glutathione and cardiovascular health.
When the researchers caused a drop in Glutathione levels in the mitochondria of cultured brain cells, the cells became more vulnerable to damage by nitric oxide or peroxynitrite.The same researchers conducted an in vivo study and determined that a partial loss of Glutathione occurs during cerebral ischemia (stroke) and persists during reperfusion (the reintroduction of blood into the blocked area).
Furthermore, infusion of Glutathione monoethylester, a compound that can increase mitochondrial glutathione, decreased the volume of the area deprived of blood.
The researchers concluded, “Together these recent findings indicate that alterations in mitochondrial Glutathione are likely to contribute to the severity of tissue damage in stroke and possibly other neurological disorders.” By Kimberly Pryor
3 Mean totalGlutathione concentrations were lower in all cardiovascular disease cases than in control subjects. Among subgroups of subjects with different types of cardiovascular disease, both the cerebral infarction cases and cerebral hemorrhage cases had significantly lower Glutathione levels than the corresponding control groups.
After adjustment for other confounding factors, the risk of cardiovascular disease was significantly lower in the subjects with the highest Glutathione levels compared to the subjects with the lowest levels. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage.
According to the study authors, “These findings suggest that reduced plasma total Glutathione levels are a risk factor for CVD, especially for cerebral small vessel disease.”Australian researchers established a similar link between Glutathione and cardiovascular health.
When the researchers caused a drop in Glutathione levels in the mitochondria of cultured brain cells, the cells became more vulnerable to damage by nitric oxide or peroxynitrite.The same researchers conducted an in vivo study and determined that a partial loss of Glutathione occurs during cerebral ischemia (stroke) and persists during reperfusion (the reintroduction of blood into the blocked area).
Furthermore, infusion of Glutathione monoethylester, a compound that can increase mitochondrial glutathione, decreased the volume of the area deprived of blood.
The researchers concluded, “Together these recent findings indicate that alterations in mitochondrial Glutathione are likely to contribute to the severity of tissue damage in stroke and possibly other neurological disorders.” By Kimberly Pryor
Antioxidant Supports Lung, Liver, Gastric and Cerebral Health while Guarding Against DNA Damage
Glutathione is the king of all antioxidants.
It rules our body’s cells, for without it, they would be helpless during the fatal onslaught of free radicals.
Glutathione plays a prominent role in regulation of cellular events including gene expression, DNA and protein synthesis, cell proliferation and apoptosis (programmed cell death), and immune response.
Glutathione deficiency contributes to oxidative stress, which is involved in aging and the development of such diseases as Alzheimer’s, Parkinson's, liver disease, cystic fibrosis, sickle cell anemia, HIV and AIDS, cancer, strokes—even H. pylori infections.1-2 Recently, an abundance of research has emerged on Glutathione’s role in health. By Kimberly Pryor
It rules our body’s cells, for without it, they would be helpless during the fatal onslaught of free radicals.
Glutathione plays a prominent role in regulation of cellular events including gene expression, DNA and protein synthesis, cell proliferation and apoptosis (programmed cell death), and immune response.
Glutathione deficiency contributes to oxidative stress, which is involved in aging and the development of such diseases as Alzheimer’s, Parkinson's, liver disease, cystic fibrosis, sickle cell anemia, HIV and AIDS, cancer, strokes—even H. pylori infections.1-2 Recently, an abundance of research has emerged on Glutathione’s role in health. By Kimberly Pryor
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