HOW TO GET GLUTATHIONE INTO YOUR CELLS

Glutathione is made up of three amino acids, glycine, glutamic acid and cysteine. Each cell produces its own GSH according to need within itself.

The determining factor as to how much it can make to ultimately keep levels up to the needed 70% in the active form...is determined by the availability of the amino acid cysteine. The production of cysteine becomes less and less efficient as we get older going into a steady decline by around age 55 onward.

This is just at a time when its most needed to protect our brains and neurological system from syndromes such as Alzheimer's Disease and dementia, which are now becoming more and more common.

Before we go further, let me explain "active" form (technically called the "reduced" form) and "inactive" (technically called the "oxidized" form) forms of glutathione. The active form is the one that can perform all the functions listed above act as a powerful antioxidant, work to combat diseases of aging and a potent player in detoxification. It is often shown in written works as "GSH".

The inactive form is present when GSH has done its work donating electrons and needs to regenerate itself which it can do. Its usually shown as GSSG (lacking the H..because it gave it away to stabilize some other molecule).

In a healthy situation, the percentage of GSH is about 90% with only 10% of Glutathione existing as GSSG. When these ratios change and there is more and more GSSG present, that is when the cell becomes sick, and is vulnerable to attack from toxins and microbes. If GSH falls below 70%...the cells/organ/person is in HUGE trouble!

There is one provison to this situation. If GSH is "used" to clear up a situation from our own metabolism, then it can regenerate itself just fine. HOWEVER if its used to combat "xenobiotics" or toxins from the outside of our bodies, such as chemicals, heavy metals, toxins, etc., then it cant regenerate.

This is where we run into trouble today as our food is not replenishing us the way it should and supplementing for Glutathione is tricky

Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier

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Alzheimer's Disease and Glutathione

Free radicals and oxidative damage in neurons is known to be a primary cause of degenerative diseases like Alzheimer's disease.'

Amyloid-Я peptide (AЯ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration.

Amyloid plaques encroaching on the brain increase the production of free radicals, or oxidative stress. Antioxidants, such as vitamin C and E "mop up" the damaging free radicals.

Glutathione (GSH ) precursors can prevent death of brain cells induced by amyloid plaques in Alzheimer's disease, while substances that deplete GSH increase cell death.

Evidence has been piling up over the link between the amount of an amino acid called homocysteine in the blood and the chance of developing Alzheimer's.

For people not genetically predisposed to developing Alzheimer's, cholesterol and homocysteine, largely caused by an unhealthy lifestyle, are the core causal factors.

Welsh GP, Andrew McCaddon, showed that the more homocysteine that patients with Alzheimer's had, the worse their mental performance, and the worse their "cognitive impairment," the less they had of the antioxidant Glutathione.

The Journal of Cell Biology, Volume 164, Number 1, 123-131; 5 January 2004
Biol Psychiatry. 2003 Feb;53(3):254-60

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Brain Disorders and Glutathione

A Genetic Cause?

Genetics researchers have found that the Glutathione S-transferase gene controls the onset of Alzheimer's, Parkinson's disease and determines, not if we get these diseases, but when.

The Glutathione S-transferase gene has previously been linked to the risk for Parkinson's disease among people who used pesticides.

Human Molecular Genetics, 2003, Vol. 12, No. 24 3259-3267

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Antioxidant Supports Lung, Liver, Gastric and Cerebral Health while Guarding Against DNA Damage

Glutathione is the king of all antioxidants.

It rules our body’s cells, for without it, they would be helpless during the fatal onslaught of free radicals.

Glutathione plays a prominent role in regulation of cellular events including gene expression, DNA and protein synthesis, cell proliferation and apoptosis (programmed cell death), and immune response.

Glutathione deficiency contributes to oxidative stress, which is involved in aging and the development of such diseases as Alzheimer’s, Parkinson's, liver disease, cystic fibrosis, sickle cell anemia, HIV and AIDS, cancer, strokes—even H. pylori infections.1-2 Recently, an abundance of research has emerged on Glutathione’s role in health. By Kimberly Pryor