Glutathione is a tri-peptide composed of three amino acids: Cysteine, Glutamic Acid and Glycine.
Glutathione and the enzymes it forms, such as GTH peroxidase, are essential to all life and are found in tissues of virtually all plants and animals. GTH is present in all human cells, with the highest levels found in the liver, the lenses of the eyes, pancreas, spleen and kidneys.
Glutathione acts as a powerful antioxidant, a key protector against all types of pollution and is effective in preventing aging. It protects DNA and RNA from free-radical damage.
Glutathione also protects against cellular peroxidation caused by exposure to pesticides, plastics, benzene and carbon tetrachloride, as well as heavy metals, cigarette smoke, smog, drugs, solvents, dyes, phenols and nitrates.
Glutathione works to inhibit the formation of free radicals, dangerous agents that suppress the immune system and promote the formation of mutagens and carcinogens.
Free radicals also speed up the aging process, and it is due to this powerful antioxidant activity that Glutathione is considered useful in the prevention and treatment of a wide range of degenerative diseases.
Studies at the Louisville School of Medicine have clearly shown that Glutathione possesses the unique ability to slow the aging process. While Glutathione aids in the protection of all cells and membranes, a study at Harvard Medical School found that Glutathione is especially able to enhance immune system cells, protecting against damage from radiation and helping to reduce the side effects of chemotherapy and x-rays and alcohol. As a detoxifier of metals and drugs, Glutathione also aids in the treatment of blood and liver disorders.
As individuals grow older, Glutathione levels drop, and the ability to detoxify free radicals decreases.
It can protect against cadmium, copper, and acetaminophen (the active agent in Tylenol) toxicity. Glutathione aids the liver in detoxification, slows the aging process, helps the cardiovascular and immune system, and is helpful in preventing or treating many other health conditions.
Supplementation may prevent, or be helpful with, the following conditions:
Aging
Alcoholism
Asthma
Atherosclerosis (heart disease)
Cancer
Cataracts
Dizziness
Hepatitis
Immunodepression (immune function)
Infertility (male)
Memory Loss (Alzheimer's disease, dementia)
Osteoarthritis
Parkinson's Disease
Peptic Ulcers
Click here for more about Glutathione and its benefits to our body.
Showing posts with label Anti-oxidant. Show all posts
Showing posts with label Anti-oxidant. Show all posts
Thursday, February 7, 2008
Wednesday, January 23, 2008
Undenatured Whey Protein Isolate
Whey protein contains proteins like alpha-lactalbumin which is is rich in sulphur-containing amino acids.
Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity.
Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Click here for more about Glutathione and its benefits to our body.
Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity.
Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Click here for more about Glutathione and its benefits to our body.
Monday, January 21, 2008
Glutathione Fact 1 - produced naturally in our cells
Glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Friday, January 18, 2008
HOW TO GET GLUTATHIONE INTO YOUR CELLS
Glutathione is made up of three amino acids, glycine, glutamic acid and cysteine. Each cell produces its own GSH according to need within itself.
The determining factor as to how much it can make to ultimately keep levels up to the needed 70% in the active form...is determined by the availability of the amino acid cysteine. The production of cysteine becomes less and less efficient as we get older going into a steady decline by around age 55 onward.
This is just at a time when its most needed to protect our brains and neurological system from syndromes such as Alzheimer's Disease and dementia, which are now becoming more and more common.
Before we go further, let me explain "active" form (technically called the "reduced" form) and "inactive" (technically called the "oxidized" form) forms of glutathione. The active form is the one that can perform all the functions listed above act as a powerful antioxidant, work to combat diseases of aging and a potent player in detoxification. It is often shown in written works as "GSH".
The inactive form is present when GSH has done its work donating electrons and needs to regenerate itself which it can do. Its usually shown as GSSG (lacking the H..because it gave it away to stabilize some other molecule).
In a healthy situation, the percentage of GSH is about 90% with only 10% of Glutathione existing as GSSG. When these ratios change and there is more and more GSSG present, that is when the cell becomes sick, and is vulnerable to attack from toxins and microbes. If GSH falls below 70%...the cells/organ/person is in HUGE trouble!
There is one provison to this situation. If GSH is "used" to clear up a situation from our own metabolism, then it can regenerate itself just fine. HOWEVER if its used to combat "xenobiotics" or toxins from the outside of our bodies, such as chemicals, heavy metals, toxins, etc., then it cant regenerate.
This is where we run into trouble today as our food is not replenishing us the way it should and supplementing for Glutathione is tricky
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Learn more about Glutathione click here
The determining factor as to how much it can make to ultimately keep levels up to the needed 70% in the active form...is determined by the availability of the amino acid cysteine. The production of cysteine becomes less and less efficient as we get older going into a steady decline by around age 55 onward.
This is just at a time when its most needed to protect our brains and neurological system from syndromes such as Alzheimer's Disease and dementia, which are now becoming more and more common.
Before we go further, let me explain "active" form (technically called the "reduced" form) and "inactive" (technically called the "oxidized" form) forms of glutathione. The active form is the one that can perform all the functions listed above act as a powerful antioxidant, work to combat diseases of aging and a potent player in detoxification. It is often shown in written works as "GSH".
The inactive form is present when GSH has done its work donating electrons and needs to regenerate itself which it can do. Its usually shown as GSSG (lacking the H..because it gave it away to stabilize some other molecule).
In a healthy situation, the percentage of GSH is about 90% with only 10% of Glutathione existing as GSSG. When these ratios change and there is more and more GSSG present, that is when the cell becomes sick, and is vulnerable to attack from toxins and microbes. If GSH falls below 70%...the cells/organ/person is in HUGE trouble!
There is one provison to this situation. If GSH is "used" to clear up a situation from our own metabolism, then it can regenerate itself just fine. HOWEVER if its used to combat "xenobiotics" or toxins from the outside of our bodies, such as chemicals, heavy metals, toxins, etc., then it cant regenerate.
This is where we run into trouble today as our food is not replenishing us the way it should and supplementing for Glutathione is tricky
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Learn more about Glutathione click here
What conditions or problems is glutathione used for?
Glutathione peroxidase may help delay the physical effects and problems of aging.
Adequate amounts of Glutathione are needed to help the immune system fight against free-radical damage, infection, and illness.
Glutathione may help prevent or lessen symptoms of conditions like asthma and rheumatoid arthritis.
Learn more about Glutathione click here
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Adequate amounts of Glutathione are needed to help the immune system fight against free-radical damage, infection, and illness.
Glutathione may help prevent or lessen symptoms of conditions like asthma and rheumatoid arthritis.
Learn more about Glutathione click here
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Master Antioxidant
Despite the fact that you live in an unhealthy world, surrounded by unhealthy temptations, distractions and challenges, in one day you may…
Drive past McDonalds even when every animal instict is screaming for french fries.
Tell one of your kids you're not hungry (even though you are starving) when they wave a big spoonful of cookie dough ice cream in your face and offer to share.
Make a special trip to the whole foods store on the other side of town just to pick up and pay a hefty sum for organic, montmorency cherries because you heard how high in antioxidants they were.
Because:
Because you want to feel better!
You want more energy!
You want your clothes to fit again!
And, most importantly, you want to be healthy
So, in case you haven't met, let me introduce you to the "Master".The master antioxidant that is.
It is known as Glutathione or GSH.
Why is glutathione called the master antioxidant?
To put it simply, glutathione replenishes the action of many other antioxidants. In other words, glutathione makes those montmorency cherries go even farther as an antioxidants, enhancing the well documented and undeniable benefits of antioxidants.
For the scientific types, here is a brief explanation offered by Dr. Jimmy Gutman, a noted glutathione expert. He says,
"When vitamin C and E pick up an oxyradical they must hand it off to the GSH (glutathione) system so they are free to go back and get others. GSH similarly neutralizes peroxide and lipoic acid. In fact, all of the antioxidants help to neutralize each other and glutathione is at the center of cellular antioxidation. It is GSH -not the vitamin- that ultimately neutralizes the radical."
Perhaps, to make the point clear, you need an analogy.
Think of the activity in your body as a bustling metropolis with lots of people. Like dangerous free radicals, some of those people prowl around seeking to do harm. Fortunately, most cities have some form of Law Enforcement which, in most cases, finds and captures these less than desirables, much like your immune system which uses (among many other things) antioxidants to seek, finds and capture free radicals.
In this analogy, glutathione is like the patty wagon which then whisks the criminals away and, unlike our democratic society, makes that criminal disappear forever.
As a result, every extra "healthy" act you exert yourself to make each day is enhanced when you have optimal levels of naturally occurring glutathione in your cells.
Each supplement you take, each vitamin, each mineral, each antioxidants rich fruit and vegetable is assisted by the free radical neutralizing power of glutathione.
Click here for more about Glutathione and its benefits to our body.
Drive past McDonalds even when every animal instict is screaming for french fries.
Tell one of your kids you're not hungry (even though you are starving) when they wave a big spoonful of cookie dough ice cream in your face and offer to share.
Make a special trip to the whole foods store on the other side of town just to pick up and pay a hefty sum for organic, montmorency cherries because you heard how high in antioxidants they were.
Because:
Because you want to feel better!
You want more energy!
You want your clothes to fit again!
And, most importantly, you want to be healthy
So, in case you haven't met, let me introduce you to the "Master".The master antioxidant that is.
It is known as Glutathione or GSH.
Why is glutathione called the master antioxidant?
To put it simply, glutathione replenishes the action of many other antioxidants. In other words, glutathione makes those montmorency cherries go even farther as an antioxidants, enhancing the well documented and undeniable benefits of antioxidants.
For the scientific types, here is a brief explanation offered by Dr. Jimmy Gutman, a noted glutathione expert. He says,
"When vitamin C and E pick up an oxyradical they must hand it off to the GSH (glutathione) system so they are free to go back and get others. GSH similarly neutralizes peroxide and lipoic acid. In fact, all of the antioxidants help to neutralize each other and glutathione is at the center of cellular antioxidation. It is GSH -not the vitamin- that ultimately neutralizes the radical."
Perhaps, to make the point clear, you need an analogy.
Think of the activity in your body as a bustling metropolis with lots of people. Like dangerous free radicals, some of those people prowl around seeking to do harm. Fortunately, most cities have some form of Law Enforcement which, in most cases, finds and captures these less than desirables, much like your immune system which uses (among many other things) antioxidants to seek, finds and capture free radicals.
In this analogy, glutathione is like the patty wagon which then whisks the criminals away and, unlike our democratic society, makes that criminal disappear forever.
As a result, every extra "healthy" act you exert yourself to make each day is enhanced when you have optimal levels of naturally occurring glutathione in your cells.
Each supplement you take, each vitamin, each mineral, each antioxidants rich fruit and vegetable is assisted by the free radical neutralizing power of glutathione.
Click here for more about Glutathione and its benefits to our body.
Wednesday, January 16, 2008
Substances that Boost Glutathione Levels and Protect Brain Cells
Taking Glutathione itself as a supplement does not boost cellular Glutathione levels, since it breaks down in the digestive tract before it reaches the cells.
However, intravenous Glutathione therapy and Glutathione precursors or dietary supplements are effective in boosting intracellular levels ofGlutathione.
Intravenous Glutathione Injections:
Intravenous Glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Followingeven a single dosage of intravenous Glutathione, many of the symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.
Glutathione Precursors:
In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding theGlutathione precursor, N-acetyl-cysteine (NAC) to a protocol thatlowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all the patients.
Cucurmin (turmeric):
Studies have shown that the Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce the enzyme, hemeoxygenase-1(HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as Glutathione S-transferase.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxifies Your Body
However, intravenous Glutathione therapy and Glutathione precursors or dietary supplements are effective in boosting intracellular levels ofGlutathione.
Intravenous Glutathione Injections:
Intravenous Glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Followingeven a single dosage of intravenous Glutathione, many of the symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.
Glutathione Precursors:
In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding theGlutathione precursor, N-acetyl-cysteine (NAC) to a protocol thatlowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all the patients.
Cucurmin (turmeric):
Studies have shown that the Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce the enzyme, hemeoxygenase-1(HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as Glutathione S-transferase.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxifies Your Body
Tuesday, January 15, 2008
Glutathione and Breast Cancer
Glutathione is protein that is produced naturally in the body.
It is an immune system booster, anti-oxidant and a natural detoxifier.
According to several studies supplementary Glutathione from whey proteins promotes health in your body, even during chemotherapy and radiation treatments.
Whey protein has the highest biological value rating of any protein. When the biological value is high, that means protein is absorbed, used and retained better in the body.
Studies indicate that supplementary Glutathione reduces the levels of the bodies home made Glutathione in tumors, thereby stopping the tumors ability to grow while at the same time increasing levels of Glutathione in the rest of the body.
The higher our liver Glutathione levels rise, the more effectively our body is detoxified.
Detoxifying your body effectively is seen as an effective way to be proactive about your health.
Click here for more about Glutathione and its benefits to our body.
It is an immune system booster, anti-oxidant and a natural detoxifier.
According to several studies supplementary Glutathione from whey proteins promotes health in your body, even during chemotherapy and radiation treatments.
Whey protein has the highest biological value rating of any protein. When the biological value is high, that means protein is absorbed, used and retained better in the body.
Studies indicate that supplementary Glutathione reduces the levels of the bodies home made Glutathione in tumors, thereby stopping the tumors ability to grow while at the same time increasing levels of Glutathione in the rest of the body.
The higher our liver Glutathione levels rise, the more effectively our body is detoxified.
Detoxifying your body effectively is seen as an effective way to be proactive about your health.
Click here for more about Glutathione and its benefits to our body.
Monday, January 14, 2008
Increasing Tissue Glutathione Levels
It is clear that those with the highest Glutathione levels are likely to live the longest in the best of health. A number of ways have been demonstrated to increase Glutathione (GSH) and the Glutathione enzymes, Glutathione peroxidase (G-Px) and Glutathione reductase (GR).
Several small studies have shown that moderate, prolonged physical exercise increases Glutathione and its related enzyme levels in the blood and skeletal muscles.
Many vitamins and nutritional supplements are also Glutathione boosters. Lipoic acid, pine bark extract (pycnogenol), melatonin, bilberry, grape extract, and turmeric have all been shown to elevate Glutathione. Oral glutamine may also raise tissue Glutathione levels, although there are conflicting reports.
I used to think that oral Glutathione was destroyed in the stomach, and was not effective in raising Glutathione concentrations. However, Dr. Steve Edelson, of the Edelson Center for Environmental and Preventive Medicine in Atlanta, Georgia, kindly sent me a number of articles that convinced me otherwise. These articles demonstrated that about 80 percent of oral Glutathione is absorbed intact, and that the blood levels remain elevated for about three hours (Fig. 6)
Several small studies have shown that moderate, prolonged physical exercise increases Glutathione and its related enzyme levels in the blood and skeletal muscles.
Many vitamins and nutritional supplements are also Glutathione boosters. Lipoic acid, pine bark extract (pycnogenol), melatonin, bilberry, grape extract, and turmeric have all been shown to elevate Glutathione. Oral glutamine may also raise tissue Glutathione levels, although there are conflicting reports.
I used to think that oral Glutathione was destroyed in the stomach, and was not effective in raising Glutathione concentrations. However, Dr. Steve Edelson, of the Edelson Center for Environmental and Preventive Medicine in Atlanta, Georgia, kindly sent me a number of articles that convinced me otherwise. These articles demonstrated that about 80 percent of oral Glutathione is absorbed intact, and that the blood levels remain elevated for about three hours (Fig. 6)
Click here for more about Glutathione and its benefits to our body.
Why is Glutathione Essential to Health?
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Thursday, January 10, 2008
Glutathione and Helicobacter pylori
Helicobacter pylori is the primary cause of gastritis and peptic ulcer disease and can lead to the onset of gastric cancer.
Previous studies have shown that H. pylori infection causes increased production of reactive oxygen species within the gastric mucosa, possibly leading to the H. pylori associated diseases. One group of researchers, after reviewing the medical literature, proposed that the severity of inflammation and damage associated with H. pylori infection is dependent on stomach cells’ ability to counteract the increased reactive oxygen species load.
They hypothesized that Glutathione availability is important in mounting an adequate defense against the reactive oxygen species generated by the H. pylori infection.
The researchers suggested that increasing Glutathione availability could provide a novel method for preventing or reducing the damage caused by Helicobacter pylori. By Kimberly Pryor
Why is Glutathione Essential to Health?Glutathione's three major roles in the body are summarized by the letters A-B-C.- Anti-oxidant- Blood Booster- Cell Detoxifier
Previous studies have shown that H. pylori infection causes increased production of reactive oxygen species within the gastric mucosa, possibly leading to the H. pylori associated diseases. One group of researchers, after reviewing the medical literature, proposed that the severity of inflammation and damage associated with H. pylori infection is dependent on stomach cells’ ability to counteract the increased reactive oxygen species load.
They hypothesized that Glutathione availability is important in mounting an adequate defense against the reactive oxygen species generated by the H. pylori infection.
The researchers suggested that increasing Glutathione availability could provide a novel method for preventing or reducing the damage caused by Helicobacter pylori. By Kimberly Pryor
Why is Glutathione Essential to Health?Glutathione's three major roles in the body are summarized by the letters A-B-C.- Anti-oxidant- Blood Booster- Cell Detoxifier
Glutathione and Cancer
Free radicals are involved in the processes leading to cancer.
Unfortunately, Glutathione, which could normally help mount a defense against the free radicals, is often depleted in patients with cancer.
In one study of 52 bladder cancer patients and 24 healthy adult controls, levels of malondialdehyde, a free-radical promoting substance, were significantly higher and Glutathione levels significantly lower in cancer patients compared to controls.
In other studies of lung6 and breast cancer levels of glutathione-dependent enzymes were markedly altered, depending on the disease stage.
Animal studies also have indicated that Glutathione deficiency is linked to DNA damage.By Kimberly Pryor
Click here for more about Glutathione and its benefits to our body.
Unfortunately, Glutathione, which could normally help mount a defense against the free radicals, is often depleted in patients with cancer.
In one study of 52 bladder cancer patients and 24 healthy adult controls, levels of malondialdehyde, a free-radical promoting substance, were significantly higher and Glutathione levels significantly lower in cancer patients compared to controls.
In other studies of lung6 and breast cancer levels of glutathione-dependent enzymes were markedly altered, depending on the disease stage.
Animal studies also have indicated that Glutathione deficiency is linked to DNA damage.By Kimberly Pryor
Click here for more about Glutathione and its benefits to our body.
Wednesday, January 9, 2008
Why is Glutathione important for Sperm Quality and Fertility?
A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.
Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants. There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.
In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.
Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies. Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.
By Priya F. Shah
Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants. There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.
In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.
Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies. Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.
By Priya F. Shah
Glutathione helps immune system and as a detoxifying agent
Glutathione helps to support the proper functioning of your immune system, and will improve immune system already in retreat.
Glutathione acts as an antioxidant and free radical scavenger, thereby protecting our DNA and RDA from damage due to many environmental factors.
Glutathione acts as the regulator of other antioxidant, thereby "keeping'em all in line", so to speak.
Glutathione acts as a detoxifying agent, removing foreign objects, chemicals and toxins from the body. As you age, your levels of Glutathione are depleted, thereby allowing the aging process to accelerate. Because the body must make Glutathione, the best source of Glutathione for a compromised immune system is still MAX GXL.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
Glutathione acts as an antioxidant and free radical scavenger, thereby protecting our DNA and RDA from damage due to many environmental factors.
Glutathione acts as the regulator of other antioxidant, thereby "keeping'em all in line", so to speak.
Glutathione acts as a detoxifying agent, removing foreign objects, chemicals and toxins from the body. As you age, your levels of Glutathione are depleted, thereby allowing the aging process to accelerate. Because the body must make Glutathione, the best source of Glutathione for a compromised immune system is still MAX GXL.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
Monday, January 7, 2008
Home Treatments for Chronic Fatigue Syndrome
Exercise improves sleep quality along with myriad other health benefits, but exercise also can severely aggravate CFS. Therefore, CFS-afflicted people must strike a balance and engage in light exercise that will provide health benefits yet not stretch their energy.
A Delicate Balance
While it may be extremely painful for those with Chronic Fatigue Syndrome to even get into the shower, a sedentary lifestyle can be even worse. A range of health problems including loss of bone mass, obesity, and heart disease pose a serious threat to such a lifestyle.
However, research suggests that lactic acid, a natural by-product of exercise that causes fatigue in healthy people, is an even bigger problem for CFS sufferers. Exercise produces a flood of lactic acid and onsets CFS symptoms, and studies even suggest that those with CFS produce even more lactic acid than healthy people. Naturally, if you are a CFS patient you are frustrated.
Glutathione Strenthens your immune system Lymphocytes, cells vital for your immune system, depend on glutathione for their proper function and replication.
Baby Steps around the Chronic Fatigue Syndrome
You should always approach exercise gently and slowly. Stretching is a popular starting point, even if you do it in your bed. Consider yoga, light walking, and Tai Chi. If aerobic exercise aggravates your CFS, experiment with non- aerobic exercise like weight training.
Keep track of your exercises in your log book, and note if the exercise causes your CFS to relapse. If it does, try a lighter, shorter version of the exercise next time. Remember not to over exert yourself, and stop exercising well before you are tired.
Listen to Your Body
If you are simply not up for exercising today, or if you notice that your symptoms are worsened by exercise, don’t be discouraged. Sit out and try again tomorrow; if running for six minutes does aggravate your CFS, scale it back to five and stay there until you are ready to try again. Pushing yourself too hard can have debilitating consequences.
Adopt a Graded Exercise Program
Walking, riding a bike, and swimming are all excellent forms of aerobic exercise for people with Chronic Fatigue Syndrome. Graded exercise means you increase the intensity, duration, and frequency of physical activity very slowly.
Why is Glutathione Essential to Health?
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant
- Blood Booster
- Cell Detoxifier
A Delicate Balance
While it may be extremely painful for those with Chronic Fatigue Syndrome to even get into the shower, a sedentary lifestyle can be even worse. A range of health problems including loss of bone mass, obesity, and heart disease pose a serious threat to such a lifestyle.
However, research suggests that lactic acid, a natural by-product of exercise that causes fatigue in healthy people, is an even bigger problem for CFS sufferers. Exercise produces a flood of lactic acid and onsets CFS symptoms, and studies even suggest that those with CFS produce even more lactic acid than healthy people. Naturally, if you are a CFS patient you are frustrated.
Glutathione Strenthens your immune system Lymphocytes, cells vital for your immune system, depend on glutathione for their proper function and replication.
Baby Steps around the Chronic Fatigue Syndrome
You should always approach exercise gently and slowly. Stretching is a popular starting point, even if you do it in your bed. Consider yoga, light walking, and Tai Chi. If aerobic exercise aggravates your CFS, experiment with non- aerobic exercise like weight training.
Keep track of your exercises in your log book, and note if the exercise causes your CFS to relapse. If it does, try a lighter, shorter version of the exercise next time. Remember not to over exert yourself, and stop exercising well before you are tired.
Listen to Your Body
If you are simply not up for exercising today, or if you notice that your symptoms are worsened by exercise, don’t be discouraged. Sit out and try again tomorrow; if running for six minutes does aggravate your CFS, scale it back to five and stay there until you are ready to try again. Pushing yourself too hard can have debilitating consequences.
Adopt a Graded Exercise Program
Walking, riding a bike, and swimming are all excellent forms of aerobic exercise for people with Chronic Fatigue Syndrome. Graded exercise means you increase the intensity, duration, and frequency of physical activity very slowly.
Why is Glutathione Essential to Health?
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant
- Blood Booster
- Cell Detoxifier
Sunday, January 6, 2008
Common symptoms of Diabetes
Symptoms:
*Unusual thirst
*Frequent urination
*Extreme fatigue and weakness
*Blurred vision
*Abdominal pains
*Nausea and vomiting
*Rapid weight loss or gain
*Skin infections
*Impotence
*Fluid retention (especially in legs and feet)
*Poor healing of skin wounds
*Decreased tolerance to cold
*Chronic itching
*Irregular or rapid heart rate
*Dry scaly skin
*Numbness or tingling of fingers and toes
*Extreme hunger pangs
*Hot and sweaty with clammy perspiration
*Heart tremors and palpitations
*Apprehensive with no obvious reason
*Shaky and nervous
*Disoriented, confused, inability to concentrate
*Frequent headaches, dizziness
*Mood changes, irritability
All diabetic symptoms are related to chronically high levels of glucose in the blood, which causes the premature aging of all body parts. So all diabetic symptoms can be explained in terms of what happens to the body as it ages. The branch of science that studies the aging process is called Gerontology and much of what happens to people with uncontrolled diabetes. more...
It is well known that aging is accompanied by a precipitous fall inglutathione levels. Lower glutathione levels are implicated in manydiseases associated with aging including cataracts, Alzheimer's,Parkinson's atherosclerosis and others.Journal of Clinical Epidemiology 47:1021-26, 1994.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
If you have any of the symptoms mentioned above, a family history of diabetes, or are aged 45 or above, contact your doctor or healthcare professional and initiate blood and urine tests for diabetes.
*Unusual thirst
*Frequent urination
*Extreme fatigue and weakness
*Blurred vision
*Abdominal pains
*Nausea and vomiting
*Rapid weight loss or gain
*Skin infections
*Impotence
*Fluid retention (especially in legs and feet)
*Poor healing of skin wounds
*Decreased tolerance to cold
*Chronic itching
*Irregular or rapid heart rate
*Dry scaly skin
*Numbness or tingling of fingers and toes
*Extreme hunger pangs
*Hot and sweaty with clammy perspiration
*Heart tremors and palpitations
*Apprehensive with no obvious reason
*Shaky and nervous
*Disoriented, confused, inability to concentrate
*Frequent headaches, dizziness
*Mood changes, irritability
All diabetic symptoms are related to chronically high levels of glucose in the blood, which causes the premature aging of all body parts. So all diabetic symptoms can be explained in terms of what happens to the body as it ages. The branch of science that studies the aging process is called Gerontology and much of what happens to people with uncontrolled diabetes. more...
It is well known that aging is accompanied by a precipitous fall inglutathione levels. Lower glutathione levels are implicated in manydiseases associated with aging including cataracts, Alzheimer's,Parkinson's atherosclerosis and others.Journal of Clinical Epidemiology 47:1021-26, 1994.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
If you have any of the symptoms mentioned above, a family history of diabetes, or are aged 45 or above, contact your doctor or healthcare professional and initiate blood and urine tests for diabetes.
Glutathione infusion potentiates glucose-induced insulin secretion in aged patients with impaired glucose tolerance
OBJECTIVE: To evaluate the effect of glutathione infusion on beta-cell response to glucose in elderly people with impaired glucose tolerance (IGT).
RESEARCH DESIGN AND METHODS: Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions and during 75-g oral glucose tolerance tests and intravenous glucose tolerance tests (0.33 g.kg body wt-1.3 min-1). Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
RESULTS:In subjects with normal glucose tolerance, glutathione infusion failed to affect beta-cell response to glucose. In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT. Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM. This effect disappeared at plasma glucose levels greater than 15 mM. No effect of glutathione on insulin clearance and action was observed.
CONCLUSIONS: Glutathione infusion enhances insulin secretion in elderly people with IGT.
G Paolisso, D Giugliano, G Pizza, A Gambardella, P Tesauro, M Varricchio and F D'Onofrio Institute of Geriatric Medicine, First Medical School; University of Naples, Italy.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
RESEARCH DESIGN AND METHODS: Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions and during 75-g oral glucose tolerance tests and intravenous glucose tolerance tests (0.33 g.kg body wt-1.3 min-1). Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
RESULTS:In subjects with normal glucose tolerance, glutathione infusion failed to affect beta-cell response to glucose. In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT. Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM. This effect disappeared at plasma glucose levels greater than 15 mM. No effect of glutathione on insulin clearance and action was observed.
CONCLUSIONS: Glutathione infusion enhances insulin secretion in elderly people with IGT.
G Paolisso, D Giugliano, G Pizza, A Gambardella, P Tesauro, M Varricchio and F D'Onofrio Institute of Geriatric Medicine, First Medical School; University of Naples, Italy.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
THE EFFECTS OF STREPTOZOTOCIN DIABETES AND DIETARY IRON INTAKE ON CATALASE
THE EFFECTS OF STREPTOZOTOCIN DIABETES AND DIETARY IRON INTAKE ON CATALASE, GLUTATHIONE PEROXIDASE, SUPEROXIDE DISMUTASE AND LIPID PEROXIDATION IN CARDIAC AND SKELETAL MUSCLES OF RATS
Abstract
Catalase, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) prevent oxygen free radical mediated tissue damage. Diabetes increases and a low dietary intake of iron decreases catalase activity in muscle. Therefore, the combined effects of diabetes and iron deficiency on the free radical scavenging enzyme system and lipid peroxidation were studied. Male, weanling rats were injected with streptozotocin (65 mg/kg, IV) and fed diets containing either 35 ppm iron (Db + Fe) or 8 ppm iron (Db $-$ Fe). Sham injected animals served as iron adequate (C + Fe) or iron deficient (C $-$ Fe) controls. Heart, gastrocnemius (GT), soleus and tibialis anterior (TA) muscles were dissected, weighted and analyzed for catalase, GSH-Px and SOD activities after 3, 6 or 9 weeks on the respective diets. The TBA assay was used to assess lipid peroxidation in the GT muscle. Diabetes elevated catalase activity in all muscles while it had a slight lowering effect on SOD and GSH-Px activities in the GT and TA muscles. In the C $-$ Fe rats, catalase activity declined and remained depressed in all muscles except the heart. There was an elevation in GSH-Px and SOD in the GT muscles of these animals after 6 weeks but not after 9 weeks of consuming the low iron diet. The Db $-$ Fe animals were unable to respond to the diabetic state with catalase activity as high as observed in the Db + Fe rats. Treatment with insulin or iron returned catalase to control levels. The C $-$ Fe animals had significantly lower levels of lipid peroxidation than the other groups at 6 and 9 weeks. Refeeding an iron adequate diet resulted in an increase in lipid peroxidation levels. These studies indicate that skeletal muscle free radical scavenging enzymes are sensitive to metabolic states and that dietary iron influences lipid peroxidation in this tissue.
SYDNEY REBECCA MORROW, THE UNIVERSITY OF TEXAS GRAD. SCH. OF BIOMED. SCI. AT HOUSTON Date: 1987
Click here to demonstrate to you why glutathione is so important to your health and well-being
Abstract
Catalase, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) prevent oxygen free radical mediated tissue damage. Diabetes increases and a low dietary intake of iron decreases catalase activity in muscle. Therefore, the combined effects of diabetes and iron deficiency on the free radical scavenging enzyme system and lipid peroxidation were studied. Male, weanling rats were injected with streptozotocin (65 mg/kg, IV) and fed diets containing either 35 ppm iron (Db + Fe) or 8 ppm iron (Db $-$ Fe). Sham injected animals served as iron adequate (C + Fe) or iron deficient (C $-$ Fe) controls. Heart, gastrocnemius (GT), soleus and tibialis anterior (TA) muscles were dissected, weighted and analyzed for catalase, GSH-Px and SOD activities after 3, 6 or 9 weeks on the respective diets. The TBA assay was used to assess lipid peroxidation in the GT muscle. Diabetes elevated catalase activity in all muscles while it had a slight lowering effect on SOD and GSH-Px activities in the GT and TA muscles. In the C $-$ Fe rats, catalase activity declined and remained depressed in all muscles except the heart. There was an elevation in GSH-Px and SOD in the GT muscles of these animals after 6 weeks but not after 9 weeks of consuming the low iron diet. The Db $-$ Fe animals were unable to respond to the diabetic state with catalase activity as high as observed in the Db + Fe rats. Treatment with insulin or iron returned catalase to control levels. The C $-$ Fe animals had significantly lower levels of lipid peroxidation than the other groups at 6 and 9 weeks. Refeeding an iron adequate diet resulted in an increase in lipid peroxidation levels. These studies indicate that skeletal muscle free radical scavenging enzymes are sensitive to metabolic states and that dietary iron influences lipid peroxidation in this tissue.
SYDNEY REBECCA MORROW, THE UNIVERSITY OF TEXAS GRAD. SCH. OF BIOMED. SCI. AT HOUSTON Date: 1987
Click here to demonstrate to you why glutathione is so important to your health and well-being
Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations
Hyperglycemia-induced embryonic malformations may be due to an increase in radical formation and depletion of intracellular glutathione (GSH) in embryonic tissues. In the past, we have investigated the role of the glutathione-dependent antioxidant system and GSH on diabetes-related embryonic malformations. Embryos from streptozotocin-induced diabetic rats on gestational day 11 showed a significantly higher frequency of embryonic malformations (neural lesions 21.5 vs. 2.8%, P<0.001; GSH in embryonic tissues of diabetic pregnant rats on day 11 was significantly lower than that of normal rats. The activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting GSH synthesizing enzyme, in embryos of diabetic rats was significantly low, associated with reduced expression of gamma-GCS mRNA. Administration of buthionine sulfoxamine (BSO), a specific inhibitor of gamma-GCS, to diabetic rats during the period of maximal teratogenic susceptibility (days 6-11 of gestation) reduced GSH by 46.7% and increased the frequency of neural lesions (62.1 vs. 21.5%, P<0.01) GSH ester to diabetic rats restored GSH concentration in the embryos and reduced the formation of ROS, leading to normalization of neural lesions (1.9 vs. 21.5%) and improvement in nonneural lesions (26.7 vs. 47.4%) and growth retardation. Administration of insulin in another group of pregnant rats during the same period resulted in complete normalization of neural lesions (4.3 vs. 21.5%), nonneural lesions (4.3 vs. 47.4%), and growth retardation with the restoration of GSH contents. Our results indicate that GSH depletion and impaired responsiveness of GSH-synthesizing enzyme to oxidative stress during organogenesis may have important roles in the development of embryonic malformations in diabetes.
Click here to demonstrate to you why Glutathione is so important to your health and well-being
Click here to demonstrate to you why Glutathione is so important to your health and well-being
Abnormalities of retinal metabolism in diabetes or galactosemia
PURPOSE: Experimental galactosemia and diabetes are known to result in diabetic-like retinopathy in animals, but the mechanism by which the retinopathy develops remains unclear.
Defects of retinal metabolism that are common to galactosemia and diabetes are closely associated with the development of retinopathy and might play a role in the pathogenesis of the retinal disease.
METHODS: Effects of experimental galactosemia on retinal calcium-activated ATPase [(Ca,Mg)-ATPase], sodium-potassium ATPase [(Na,K)-ATPase], glutathione, ATP, and pertinent ions have been compared with the effects of experimental diabetes in rat and dog models of diabetic retinopathy.
RESULTS: Activities of (Ca,Mg)-ATPase and (Na,K)-ATPase were decreased as a result of either experimental galactosemia or diabetes in both the dog and the rat, and the decreases were accompanied by a diminution of reduced glutathione (GSH) in the retina. Ouabain-insensitive ATPase activity in the retina was not significantly reduced by diabetes or galactosemia, suggesting that the observed defects in (Ca,Mg)-ATPase and (Na,K)-ATPase activities were specific. The decrease of retinal GSH levels was associated with an elevated concentration of oxidized glutathione in diabetes but not in galactosemia. Retinal ATP and ion concentrations remained unaffected by experimental galactosemia or diabetes.
CONCLUSIONS: Comparison of two etiologically dissimilar models of diabetic retinopathy (diabetes and galactosemia) has revealed abnormalities of retinal metabolism that are shared by the two models. Further comparisons of retinal metabolism between these two models should reveal additional sequelae of hyperglycemia that are associated with, and that might play a role in, the development of diabetic retinopathy.
TS Kern, RA Kowluru and RL Engerman Department of Ophthalmology and Visual Science, University of Wisconsin- Madison 53706-1532.
Investigative Ophthalmology & Visual Science, Vol 35, 2962-2967, Copyright © 1994 by Association for Research in Vision and Ophthalmology
Defects of retinal metabolism that are common to galactosemia and diabetes are closely associated with the development of retinopathy and might play a role in the pathogenesis of the retinal disease.
METHODS: Effects of experimental galactosemia on retinal calcium-activated ATPase [(Ca,Mg)-ATPase], sodium-potassium ATPase [(Na,K)-ATPase], glutathione, ATP, and pertinent ions have been compared with the effects of experimental diabetes in rat and dog models of diabetic retinopathy.
RESULTS: Activities of (Ca,Mg)-ATPase and (Na,K)-ATPase were decreased as a result of either experimental galactosemia or diabetes in both the dog and the rat, and the decreases were accompanied by a diminution of reduced glutathione (GSH) in the retina. Ouabain-insensitive ATPase activity in the retina was not significantly reduced by diabetes or galactosemia, suggesting that the observed defects in (Ca,Mg)-ATPase and (Na,K)-ATPase activities were specific. The decrease of retinal GSH levels was associated with an elevated concentration of oxidized glutathione in diabetes but not in galactosemia. Retinal ATP and ion concentrations remained unaffected by experimental galactosemia or diabetes.
CONCLUSIONS: Comparison of two etiologically dissimilar models of diabetic retinopathy (diabetes and galactosemia) has revealed abnormalities of retinal metabolism that are shared by the two models. Further comparisons of retinal metabolism between these two models should reveal additional sequelae of hyperglycemia that are associated with, and that might play a role in, the development of diabetic retinopathy.
TS Kern, RA Kowluru and RL Engerman Department of Ophthalmology and Visual Science, University of Wisconsin- Madison 53706-1532.
Investigative Ophthalmology & Visual Science, Vol 35, 2962-2967, Copyright © 1994 by Association for Research in Vision and Ophthalmology
Oxidative Stress and Glutathione Synthesis in Type 2 Diabetes: a Stable Isotope Approach
Many of the complications of diabetes are linked to oxidative damage.
We set out to determine whether the reduced antioxidant capacity (as reflected by glutathione concentration) in type diabetes is due to reduced synthesis or increased consumption of glutathione(GSH), and whether short-term dietary supplementation with glycine and cysteine, precursors of GSH, would improve oxidant status.
2H2-glycine was infused for 7 hours to measure glycine kinetics and red blood cell GSH (RBC-GSH) synthesis in diabetic and euglycemic subjects. These same measurements were repeated in a subset of diabetic subjects after 2 weeks of supplementation with glycine and cysteine, the precursors of glutathione. Lipid hydroperoxide and lymphocyte glutathione concentration were also measured.
Twenty euglycemic subjects and 10 subjects with type 2 diabetes participated in the unsupplemented study.
Authors
Reeds, Peter
Jahoor, Farook
Siripoom, Mckay - BAYLOR COLLEGE/MEDICINE
Morlese, John - UNIV. WEST INDIES
Forrester, Terrence - UNIV. WEST INDIES
Jackson, Alan - ROYAL COLLEGE/PHYSICIANTS
Balasubramanyan, Ashok - BAYLOR COLLEGE/ MEDICINE
We set out to determine whether the reduced antioxidant capacity (as reflected by glutathione concentration) in type diabetes is due to reduced synthesis or increased consumption of glutathione(GSH), and whether short-term dietary supplementation with glycine and cysteine, precursors of GSH, would improve oxidant status.
2H2-glycine was infused for 7 hours to measure glycine kinetics and red blood cell GSH (RBC-GSH) synthesis in diabetic and euglycemic subjects. These same measurements were repeated in a subset of diabetic subjects after 2 weeks of supplementation with glycine and cysteine, the precursors of glutathione. Lipid hydroperoxide and lymphocyte glutathione concentration were also measured.
Twenty euglycemic subjects and 10 subjects with type 2 diabetes participated in the unsupplemented study.
Authors
Reeds, Peter
Jahoor, Farook
Siripoom, Mckay - BAYLOR COLLEGE/MEDICINE
Morlese, John - UNIV. WEST INDIES
Forrester, Terrence - UNIV. WEST INDIES
Jackson, Alan - ROYAL COLLEGE/PHYSICIANTS
Balasubramanyan, Ashok - BAYLOR COLLEGE/ MEDICINE
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