Glutathione helps to support the proper functioning of your immune system , and will improve immune system already in retreat.
Glutathione acts as an powerful antioxidant and Free radicals scavenger, thereby protecting our DNA and RDA from damage due to many environmental factors.
Glutathione acts as the regulator of other powerful antioxidant.
Glutathione acts as a detoxifying agent, removing foreign objects, chemicals and toxins from the body. As you age, your levels of Glutathione are depleted, thereby allowing the aging process to accelerate.
Levels of Glutathione can be sucessfully improved by taking a high quality nutritional supplement!
***Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
http://www.healthline.com/galecontent/glutathione
Click here for more about Glutathione and its benefits to our body.
Showing posts with label spermatozoa. Show all posts
Showing posts with label spermatozoa. Show all posts
Thursday, February 7, 2008
Tuesday, January 22, 2008
Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging rat
Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat.
by: EV Zubkova, B Robaire - Biol Reprod, Vol. 71, No. 3. (September 2004), pp. 1002-1008.
Reactive oxygen species (ROS) play a role in male infertility, where excessive amounts impair spermatozoal motility.
Epididymal antioxidant enzymes protect spermatozoa from oxidative damage in the epididymal lumen. Antioxidant secretions from the seminal vesicle protect spermatozoa after ejaculation.
As it is known that with age there is increased generation of ROS, the goals of this study were to determine how aging affects the response of antioxidant enzymes in the epididymis, seminal vesicles, and liver to l-buthionine-S,R-sulfoximine (BSO) mediated glutathione (GSH) depletion, and to examine the impact of GSH depletion on motility parameters of spermatozoa from the cauda epididymidis in young (4-mo-old) and old (21-mo-old) rats.
Levels of GSH and glutathione disulfide (GSSG), as well as activities of glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase, were measured in the caput, corpus and cauda epididymidis, seminal vesicles, and liver.
Spermatozoal motility was assessed by computer-assisted sperm analysis. Significant age-related changes in antioxidant enzyme activities were found in the liver and cauda epididymidis.
Glutathione age was most evident in the cauda epididymidis, seminal vesicles, and liver, where antioxidant enzyme activities changed significantly.
Additionally, spermatozoa motility was adversely affected after BSO treatment in both age groups, but significantly more so in older animals.
In summary, the male reproductive tissues and liver undergo age-related changes in antioxidant enzyme activities and in their response to GSH depletion.
THE MAX GXL is a PATENTED High Performance Formula which:Dramatically Raises Your Energy LevelSlows Down The Aging ProcessStrengthens Your Immune SystemFights Inflammation and Diseases of AgingImproves Athletic Performance & RecoveryDetoxify Your Body
by: EV Zubkova, B Robaire - Biol Reprod, Vol. 71, No. 3. (September 2004), pp. 1002-1008.
Reactive oxygen species (ROS) play a role in male infertility, where excessive amounts impair spermatozoal motility.
Epididymal antioxidant enzymes protect spermatozoa from oxidative damage in the epididymal lumen. Antioxidant secretions from the seminal vesicle protect spermatozoa after ejaculation.
As it is known that with age there is increased generation of ROS, the goals of this study were to determine how aging affects the response of antioxidant enzymes in the epididymis, seminal vesicles, and liver to l-buthionine-S,R-sulfoximine (BSO) mediated glutathione (GSH) depletion, and to examine the impact of GSH depletion on motility parameters of spermatozoa from the cauda epididymidis in young (4-mo-old) and old (21-mo-old) rats.
Levels of GSH and glutathione disulfide (GSSG), as well as activities of glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase, were measured in the caput, corpus and cauda epididymidis, seminal vesicles, and liver.
Spermatozoal motility was assessed by computer-assisted sperm analysis. Significant age-related changes in antioxidant enzyme activities were found in the liver and cauda epididymidis.
Glutathione age was most evident in the cauda epididymidis, seminal vesicles, and liver, where antioxidant enzyme activities changed significantly.
Additionally, spermatozoa motility was adversely affected after BSO treatment in both age groups, but significantly more so in older animals.
In summary, the male reproductive tissues and liver undergo age-related changes in antioxidant enzyme activities and in their response to GSH depletion.
THE MAX GXL is a PATENTED High Performance Formula which:Dramatically Raises Your Energy LevelSlows Down The Aging ProcessStrengthens Your Immune SystemFights Inflammation and Diseases of AgingImproves Athletic Performance & RecoveryDetoxify Your Body
Wednesday, January 9, 2008
How can Glutathione help in the Treatment of Infertility?
Glutathione is not only vital to sperm antioxidant defenses, but selenium and Glutathione are essential to the formation of "phospholipid hydroperoxide Glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.
When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.
Free radical scavengers - such as Glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.
In a double-blind cross-over study of twenty infertile men, treatment with Glutathione led to a statistically significant improvement of the sperm quality.
The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.
Treatment with Glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology. The findings of these studies indicate that Glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.
By Priya F. Shah
Click here for more about Glutathione and its benefits to our body.
When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.
Free radical scavengers - such as Glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.
In a double-blind cross-over study of twenty infertile men, treatment with Glutathione led to a statistically significant improvement of the sperm quality.
The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.
Treatment with Glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology. The findings of these studies indicate that Glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.
By Priya F. Shah
Click here for more about Glutathione and its benefits to our body.
Why is Glutathione important for Sperm Quality and Fertility?
A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress.
Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants. There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.
In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.
Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies. Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.
By Priya F. Shah
Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. Compared with a control group, the infertile men in all groups had significantly higher levels of ROS and lower levels of total antioxidants. There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm.
In some groups, higher levels of ROS were associated with lower sperm counts and defective sperm structure, while lower antioxidant levels correlated with reduced sperm movement.Previous evidence has also shown that oxidative stress can decrease a sperm's life span, its motility, and its ability to penetrate the oocyst, or egg cell.
Up to 40% of men with unexplained male infertility have higher levels of free radical activity in their bodies. Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality.
By Priya F. Shah
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