Glutathione is not only vital to sperm antioxidant defenses, but selenium and Glutathione are essential to the formation of "phospholipid hydroperoxide Glutathione peroxidase" - an enzyme present in spermatids - which becomes a structural protein in the mid-piece of mature spermatozoa.
When either substance is deficient, it can lead to instability of the mid-piece of the spermatozoa, resulting in defective motility.
Free radical scavengers - such as Glutathione - that restore the structure and function of poly-unsaturated fatty acids (PUFA) in the cell membrane, can be used to treat these cases.
In a double-blind cross-over study of twenty infertile men, treatment with Glutathione led to a statistically significant improvement of the sperm quality.
The study concerned men in whom the sperm quality was poor due to unilateral varicocele or germ-free genital tract inflammation - two conditions in which ROS or other toxic compounds are indicated as causative factors.
Treatment with Glutathione was also found to have a statistically significantly positive effect on sperm motility (in particular forward motility) and on sperm morphology. The findings of these studies indicate that Glutathione therapy could represent a possible therapeutical tool in cases where ROS or exposure to toxins is the probable cause of infertility.
By Priya F. Shah
Click here for more about Glutathione and its benefits to our body.
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