Free radicals and oxyradicals play an important role in the development and progression of many brain disorders such as brain injury, neurodegenerative disease, schizophrenia and Down syndrome.
Glutathione is the brain's master antioxidant and plays an important protective role in the brain.
According to Dr. Jimmy Gutman, "The brain is particularly susceptible to free radical attack because it generates more oxidative by-products per gram of tissue than any other organ."
Many neurological and psychiatric disease processes are characterized by abnormalities Glutathione metabolism and antioxidant defenses.
Generation of reactive oxygen species (free radicals) and oxidative damage are an important cause of neuron (brain cell) death from brain injury.
Chemicals that cause toxicity to certain brain cells are known to decrease cerebral Glutathione (GSH), making the cells more vulnerable to reactive oxygen species (ROS).
On the other hand, over-expression of the Glutathione peroxidase (GPX) enzyme potently decreases cell death from brain injury.
Journal of Neurochemistry, Vol. 88, No. 3, 2004 513-531
Journal of Neurochemistry, Vol. 87, No. 6, 2003 1527-1534
Click here for more about Glutathione and its benefits to our body.
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