How might glutathione work in the treatment of Parkinson's disease?
Can oxidative stress play a role the genesis of Parkinson's disease? Glutathione is a potent anti-oxidant that is capable of penetrating the central nervous system (brain). According to Dr. David Perlmutter's research on alterations in glutathione levels, there seems to be both a clinical and neuropathological difference in Parkinson's disease patients treated with glutathione versus control groups. Dr. Perlmutter measured both glutathione levels and oxidized glutathione levels primarily in the substantia nigra (portion of the brain most affected in Parkinson's disease) in Parkinson's disease patients and in control groups. glutathione levels were reduced approximately 40% and oxidized glutathione was increased approximately 29% in the patients with Parkinson's disease. As he points out, this altered glutathione/oxidized glutathione ratio in the substantia nigra suggests that oxidative stress may be a component in the pathogenesis of nigral cell death in Parkinson's disease.
Furthermore, the degree of reduction in glutathione seems to parallel the severity of the Parkinson's disease. Initial studies were done on patients with early, untreated Parkinson's disease.
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