Glutathione is a tri-peptide composed of three amino acids: Cysteine, Glutamic Acid and Glycine.
Glutathione and the enzymes it forms, such as GTH peroxidase, are essential to all life and are found in tissues of virtually all plants and animals. GTH is present in all human cells, with the highest levels found in the liver, the lenses of the eyes, pancreas, spleen and kidneys.
Glutathione acts as a powerful antioxidant, a key protector against all types of pollution and is effective in preventing aging. It protects DNA and RNA from free-radical damage.
Glutathione also protects against cellular peroxidation caused by exposure to pesticides, plastics, benzene and carbon tetrachloride, as well as heavy metals, cigarette smoke, smog, drugs, solvents, dyes, phenols and nitrates.
Glutathione works to inhibit the formation of free radicals, dangerous agents that suppress the immune system and promote the formation of mutagens and carcinogens.
Free radicals also speed up the aging process, and it is due to this powerful antioxidant activity that Glutathione is considered useful in the prevention and treatment of a wide range of degenerative diseases.
Studies at the Louisville School of Medicine have clearly shown that Glutathione possesses the unique ability to slow the aging process. While Glutathione aids in the protection of all cells and membranes, a study at Harvard Medical School found that Glutathione is especially able to enhance immune system cells, protecting against damage from radiation and helping to reduce the side effects of chemotherapy and x-rays and alcohol. As a detoxifier of metals and drugs, Glutathione also aids in the treatment of blood and liver disorders.
As individuals grow older, Glutathione levels drop, and the ability to detoxify free radicals decreases.
It can protect against cadmium, copper, and acetaminophen (the active agent in Tylenol) toxicity. Glutathione aids the liver in detoxification, slows the aging process, helps the cardiovascular and immune system, and is helpful in preventing or treating many other health conditions.
Supplementation may prevent, or be helpful with, the following conditions:
Aging
Alcoholism
Asthma
Atherosclerosis (heart disease)
Cancer
Cataracts
Dizziness
Hepatitis
Immunodepression (immune function)
Infertility (male)
Memory Loss (Alzheimer's disease, dementia)
Osteoarthritis
Parkinson's Disease
Peptic Ulcers
Click here for more about Glutathione and its benefits to our body.
Showing posts with label Cell Detoxifier. Show all posts
Showing posts with label Cell Detoxifier. Show all posts
Thursday, February 7, 2008
Wednesday, January 23, 2008
Undenatured Whey Protein Isolate
Whey protein contains proteins like alpha-lactalbumin which is is rich in sulphur-containing amino acids.
Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity.
Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Click here for more about Glutathione and its benefits to our body.
Heating or pasteurization destroys the delicate disulphide bonds that give these proteins their bioactivity.
Undenatured whey protein is a non-heated product that preserves bioactive amino acids like cystine. It has been shown in numerous scientific studies and clinical trials to optimize glutathione levels.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Click here for more about Glutathione and its benefits to our body.
Monday, January 21, 2008
Glutathione Fact 1 - produced naturally in our cells
Glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Friday, January 18, 2008
HOW TO GET GLUTATHIONE INTO YOUR CELLS
Glutathione is made up of three amino acids, glycine, glutamic acid and cysteine. Each cell produces its own GSH according to need within itself.
The determining factor as to how much it can make to ultimately keep levels up to the needed 70% in the active form...is determined by the availability of the amino acid cysteine. The production of cysteine becomes less and less efficient as we get older going into a steady decline by around age 55 onward.
This is just at a time when its most needed to protect our brains and neurological system from syndromes such as Alzheimer's Disease and dementia, which are now becoming more and more common.
Before we go further, let me explain "active" form (technically called the "reduced" form) and "inactive" (technically called the "oxidized" form) forms of glutathione. The active form is the one that can perform all the functions listed above act as a powerful antioxidant, work to combat diseases of aging and a potent player in detoxification. It is often shown in written works as "GSH".
The inactive form is present when GSH has done its work donating electrons and needs to regenerate itself which it can do. Its usually shown as GSSG (lacking the H..because it gave it away to stabilize some other molecule).
In a healthy situation, the percentage of GSH is about 90% with only 10% of Glutathione existing as GSSG. When these ratios change and there is more and more GSSG present, that is when the cell becomes sick, and is vulnerable to attack from toxins and microbes. If GSH falls below 70%...the cells/organ/person is in HUGE trouble!
There is one provison to this situation. If GSH is "used" to clear up a situation from our own metabolism, then it can regenerate itself just fine. HOWEVER if its used to combat "xenobiotics" or toxins from the outside of our bodies, such as chemicals, heavy metals, toxins, etc., then it cant regenerate.
This is where we run into trouble today as our food is not replenishing us the way it should and supplementing for Glutathione is tricky
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Learn more about Glutathione click here
The determining factor as to how much it can make to ultimately keep levels up to the needed 70% in the active form...is determined by the availability of the amino acid cysteine. The production of cysteine becomes less and less efficient as we get older going into a steady decline by around age 55 onward.
This is just at a time when its most needed to protect our brains and neurological system from syndromes such as Alzheimer's Disease and dementia, which are now becoming more and more common.
Before we go further, let me explain "active" form (technically called the "reduced" form) and "inactive" (technically called the "oxidized" form) forms of glutathione. The active form is the one that can perform all the functions listed above act as a powerful antioxidant, work to combat diseases of aging and a potent player in detoxification. It is often shown in written works as "GSH".
The inactive form is present when GSH has done its work donating electrons and needs to regenerate itself which it can do. Its usually shown as GSSG (lacking the H..because it gave it away to stabilize some other molecule).
In a healthy situation, the percentage of GSH is about 90% with only 10% of Glutathione existing as GSSG. When these ratios change and there is more and more GSSG present, that is when the cell becomes sick, and is vulnerable to attack from toxins and microbes. If GSH falls below 70%...the cells/organ/person is in HUGE trouble!
There is one provison to this situation. If GSH is "used" to clear up a situation from our own metabolism, then it can regenerate itself just fine. HOWEVER if its used to combat "xenobiotics" or toxins from the outside of our bodies, such as chemicals, heavy metals, toxins, etc., then it cant regenerate.
This is where we run into trouble today as our food is not replenishing us the way it should and supplementing for Glutathione is tricky
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Learn more about Glutathione click here
What conditions or problems is glutathione used for?
Glutathione peroxidase may help delay the physical effects and problems of aging.
Adequate amounts of Glutathione are needed to help the immune system fight against free-radical damage, infection, and illness.
Glutathione may help prevent or lessen symptoms of conditions like asthma and rheumatoid arthritis.
Learn more about Glutathione click here
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Adequate amounts of Glutathione are needed to help the immune system fight against free-radical damage, infection, and illness.
Glutathione may help prevent or lessen symptoms of conditions like asthma and rheumatoid arthritis.
Learn more about Glutathione click here
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Thursday, January 17, 2008
The 3 Distinct Benefits of Naturally Produced Glutathione
Glutathione: The Master Antioxidant
Antioxidants participate directly in the destruction of reactive oxygen compounds called free radicals. These by-products of a cell’s normal function can’t be avoided, but exposure to ultraviolet radiation from the sun or other sources promotes their emergence.
Free radicals have been linked to muscle fatigue during exercise and aging.
For this reason, the body is equipped with a variety of antioxidants. Vitamins C and E are natural antioxidants but do not occur naturally in the body.
These and other antioxidants actually depend on natural glutathione to function properly.
This is why Glutathione is called “The Master Antioxidant”.
Glutathione : Food for the Immune system
Glutathione helps build your Immune system resistance and improve your chances of staying healthy.
Lymphocytes are cells of your Immune system. Glutathione is essential for lymphocytes to increase in number, produce antibodies, and function efficiently.
Glutathione: A Cellular Level Detoxifier
Our food and water sources are becoming increasingly contaminated with chemicals, as is the air that we breathe.
Supplemental Detoxifier such as Glutathione help to counter the effects of the toxins we inhale and ingest.
By physically binding to toxic compounds in cells, Glutathione helps make them soluble - and harmless. The body can then eliminate these disarmed toxins in the bile and urine.
Click here for more about Glutathione and its benefits to our body.
Antioxidants participate directly in the destruction of reactive oxygen compounds called free radicals. These by-products of a cell’s normal function can’t be avoided, but exposure to ultraviolet radiation from the sun or other sources promotes their emergence.
Free radicals have been linked to muscle fatigue during exercise and aging.
For this reason, the body is equipped with a variety of antioxidants. Vitamins C and E are natural antioxidants but do not occur naturally in the body.
These and other antioxidants actually depend on natural glutathione to function properly.
This is why Glutathione is called “The Master Antioxidant”.
Glutathione : Food for the Immune system
Glutathione helps build your Immune system resistance and improve your chances of staying healthy.
Lymphocytes are cells of your Immune system. Glutathione is essential for lymphocytes to increase in number, produce antibodies, and function efficiently.
Glutathione: A Cellular Level Detoxifier
Our food and water sources are becoming increasingly contaminated with chemicals, as is the air that we breathe.
Supplemental Detoxifier such as Glutathione help to counter the effects of the toxins we inhale and ingest.
By physically binding to toxic compounds in cells, Glutathione helps make them soluble - and harmless. The body can then eliminate these disarmed toxins in the bile and urine.
Click here for more about Glutathione and its benefits to our body.
Wednesday, January 16, 2008
Substances that Boost Glutathione Levels and Protect Brain Cells
Taking Glutathione itself as a supplement does not boost cellular Glutathione levels, since it breaks down in the digestive tract before it reaches the cells.
However, intravenous Glutathione therapy and Glutathione precursors or dietary supplements are effective in boosting intracellular levels ofGlutathione.
Intravenous Glutathione Injections:
Intravenous Glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Followingeven a single dosage of intravenous Glutathione, many of the symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.
Glutathione Precursors:
In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding theGlutathione precursor, N-acetyl-cysteine (NAC) to a protocol thatlowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all the patients.
Cucurmin (turmeric):
Studies have shown that the Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce the enzyme, hemeoxygenase-1(HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as Glutathione S-transferase.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxifies Your Body
However, intravenous Glutathione therapy and Glutathione precursors or dietary supplements are effective in boosting intracellular levels ofGlutathione.
Intravenous Glutathione Injections:
Intravenous Glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Followingeven a single dosage of intravenous Glutathione, many of the symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.
Glutathione Precursors:
In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding theGlutathione precursor, N-acetyl-cysteine (NAC) to a protocol thatlowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all the patients.
Cucurmin (turmeric):
Studies have shown that the Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce the enzyme, hemeoxygenase-1(HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as Glutathione S-transferase.
Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxifies Your Body
Monday, January 14, 2008
Increasing Tissue Glutathione Levels
It is clear that those with the highest Glutathione levels are likely to live the longest in the best of health. A number of ways have been demonstrated to increase Glutathione (GSH) and the Glutathione enzymes, Glutathione peroxidase (G-Px) and Glutathione reductase (GR).
Several small studies have shown that moderate, prolonged physical exercise increases Glutathione and its related enzyme levels in the blood and skeletal muscles.
Many vitamins and nutritional supplements are also Glutathione boosters. Lipoic acid, pine bark extract (pycnogenol), melatonin, bilberry, grape extract, and turmeric have all been shown to elevate Glutathione. Oral glutamine may also raise tissue Glutathione levels, although there are conflicting reports.
I used to think that oral Glutathione was destroyed in the stomach, and was not effective in raising Glutathione concentrations. However, Dr. Steve Edelson, of the Edelson Center for Environmental and Preventive Medicine in Atlanta, Georgia, kindly sent me a number of articles that convinced me otherwise. These articles demonstrated that about 80 percent of oral Glutathione is absorbed intact, and that the blood levels remain elevated for about three hours (Fig. 6)
Several small studies have shown that moderate, prolonged physical exercise increases Glutathione and its related enzyme levels in the blood and skeletal muscles.
Many vitamins and nutritional supplements are also Glutathione boosters. Lipoic acid, pine bark extract (pycnogenol), melatonin, bilberry, grape extract, and turmeric have all been shown to elevate Glutathione. Oral glutamine may also raise tissue Glutathione levels, although there are conflicting reports.
I used to think that oral Glutathione was destroyed in the stomach, and was not effective in raising Glutathione concentrations. However, Dr. Steve Edelson, of the Edelson Center for Environmental and Preventive Medicine in Atlanta, Georgia, kindly sent me a number of articles that convinced me otherwise. These articles demonstrated that about 80 percent of oral Glutathione is absorbed intact, and that the blood levels remain elevated for about three hours (Fig. 6)
Click here for more about Glutathione and its benefits to our body.
Why is Glutathione Essential to Health?
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Thursday, January 10, 2008
Glutathione and Helicobacter pylori
Helicobacter pylori is the primary cause of gastritis and peptic ulcer disease and can lead to the onset of gastric cancer.
Previous studies have shown that H. pylori infection causes increased production of reactive oxygen species within the gastric mucosa, possibly leading to the H. pylori associated diseases. One group of researchers, after reviewing the medical literature, proposed that the severity of inflammation and damage associated with H. pylori infection is dependent on stomach cells’ ability to counteract the increased reactive oxygen species load.
They hypothesized that Glutathione availability is important in mounting an adequate defense against the reactive oxygen species generated by the H. pylori infection.
The researchers suggested that increasing Glutathione availability could provide a novel method for preventing or reducing the damage caused by Helicobacter pylori. By Kimberly Pryor
Why is Glutathione Essential to Health?Glutathione's three major roles in the body are summarized by the letters A-B-C.- Anti-oxidant- Blood Booster- Cell Detoxifier
Previous studies have shown that H. pylori infection causes increased production of reactive oxygen species within the gastric mucosa, possibly leading to the H. pylori associated diseases. One group of researchers, after reviewing the medical literature, proposed that the severity of inflammation and damage associated with H. pylori infection is dependent on stomach cells’ ability to counteract the increased reactive oxygen species load.
They hypothesized that Glutathione availability is important in mounting an adequate defense against the reactive oxygen species generated by the H. pylori infection.
The researchers suggested that increasing Glutathione availability could provide a novel method for preventing or reducing the damage caused by Helicobacter pylori. By Kimberly Pryor
Why is Glutathione Essential to Health?Glutathione's three major roles in the body are summarized by the letters A-B-C.- Anti-oxidant- Blood Booster- Cell Detoxifier
Monday, January 7, 2008
How Do You Know If You Have Chronic Fatigue Syndrome?
Symptoms of CFS
Extreme Exhaustion.
You may be getting plenty of rest and sleep, but can’t seem to shake off the deep feeling if tiredness that consumes your body. This is probably the most common symptom of CFS and often robs the sufferer the ability to concentrate or become highly active; physically or mentally.
Headache.
Headaches are fairly common, so how can you tell if it has something to do with chronic fatigue syndrome? Often, CFS patients describe headaches as a type they have never experienced before, whether it be in pattern or severity. If you are not used to headaches, and are starting to get them frequently, or in a particular area, or of a particular strength, this may be related to chronic fatique syndrome.
Weakness, Aches and Pains.
Muscle ache and pain that you are not used to feeling may appear in areas of your body. Lymph nodes in the upper body, around the neck or in armpits, may become swollen and tender.
Flu Like Symptoms.
Many people diagnosed with CFS report that it started with feelings of the flu. Being tired and having headaches both tie into this symptom. Some experience a sore throat, or feel generally “out of sorts”. Clammy hands and feet, rapid breathing, brisk heartbeat and chest pain are also symptoms of this ailment.
Loss of Memory.
Loss of memory is common among CFS patients and can affect your life in various way. This particular symptom can come and go as CFS persists and thrives in your body.
Chronic Fatigue Syndrome is a Real Disease
Many people have a hard time accepting CFS as a legitimate disease. Your doctor, however will tell you that it is a very real, very life damaging disease that must be dealt with. Since many scientist and physicians believe this disease attacks when and because your immune system is weakend, it is important to keep it strong and healthy.
Natural products like Glutathione MAXGXL boost and maintain energy levels and normalize your immune system without harmful side effects. Keep in mind that CFS is a real problem that should be dealt with before it damages your life!
Click here to demonstrate to you why glutathione is so important to your health and well-being.
Extreme Exhaustion.
You may be getting plenty of rest and sleep, but can’t seem to shake off the deep feeling if tiredness that consumes your body. This is probably the most common symptom of CFS and often robs the sufferer the ability to concentrate or become highly active; physically or mentally.
Headache.
Headaches are fairly common, so how can you tell if it has something to do with chronic fatigue syndrome? Often, CFS patients describe headaches as a type they have never experienced before, whether it be in pattern or severity. If you are not used to headaches, and are starting to get them frequently, or in a particular area, or of a particular strength, this may be related to chronic fatique syndrome.
Weakness, Aches and Pains.
Muscle ache and pain that you are not used to feeling may appear in areas of your body. Lymph nodes in the upper body, around the neck or in armpits, may become swollen and tender.
Flu Like Symptoms.
Many people diagnosed with CFS report that it started with feelings of the flu. Being tired and having headaches both tie into this symptom. Some experience a sore throat, or feel generally “out of sorts”. Clammy hands and feet, rapid breathing, brisk heartbeat and chest pain are also symptoms of this ailment.
Loss of Memory.
Loss of memory is common among CFS patients and can affect your life in various way. This particular symptom can come and go as CFS persists and thrives in your body.
Chronic Fatigue Syndrome is a Real Disease
Many people have a hard time accepting CFS as a legitimate disease. Your doctor, however will tell you that it is a very real, very life damaging disease that must be dealt with. Since many scientist and physicians believe this disease attacks when and because your immune system is weakend, it is important to keep it strong and healthy.
Natural products like Glutathione MAXGXL boost and maintain energy levels and normalize your immune system without harmful side effects. Keep in mind that CFS is a real problem that should be dealt with before it damages your life!
Click here to demonstrate to you why glutathione is so important to your health and well-being.
Other symptoms associated with Fibromyalgia
* Pain in muscles
* Weariness
*Sleeplessness
* Pain in joints
* Restless legs
* Headaches
* A tingling feeling, or feeling of numbness
* Memory impairment
* Feeling nervous
* Feeling depressed
You can do the following:
If you are diagnosed with Fibromyalgia, your doctor will prescribe medication and/or therapy for you.
But there are some personal management techniques that you can also employ:
* Make sure you take some time each day to relax and detox
* Wake up and go to bed at the same time each day, and make sure you get enough sleep
* Exercise on a regular basis; start out slowly and work toward more strenuous activities
* Educate yourself to keep up with the latest research
* Look for a support group
Click here to demonstrate to you why glutathione is so important to your health and well-being.
* Weariness
*Sleeplessness
* Pain in joints
* Restless legs
* Headaches
* A tingling feeling, or feeling of numbness
* Memory impairment
* Feeling nervous
* Feeling depressed
You can do the following:
If you are diagnosed with Fibromyalgia, your doctor will prescribe medication and/or therapy for you.
But there are some personal management techniques that you can also employ:
* Make sure you take some time each day to relax and detox
* Wake up and go to bed at the same time each day, and make sure you get enough sleep
* Exercise on a regular basis; start out slowly and work toward more strenuous activities
* Educate yourself to keep up with the latest research
* Look for a support group
Click here to demonstrate to you why glutathione is so important to your health and well-being.
History of Fibromyalgia
Even though Fibromyalgia has been around for hundreds of years, it remains a mystery to this day. It has been known by many different names, like chronic muscle pain syndrome, fibrositis, tension myalgias and psychogenic rheumatism.
Fibromyalgia is a combination of Greek words:
“Fibro,” meaning fiber
“My,” meaning muscle
“Algia,” meaning pain
History:
1800s Fibromyalgia was first described doctors. They called it muscular rheumatism.
1824 A doctor in Edinburgh described the “tender points” associated with Fibromyalgia
1880 Another doctor, describing the same condition, named it neurasthenia.
1904 An article referred to it as fibrositis. (“itis” means inflammation.)
1913 A physician named Luff noted that fibromyalgia symptoms changed as barometric pressure lowered as a storm approached.
1976 The term Fibromyalgia replaces the term fibrositis, recognizing that the condition is not caused by inflammation.
1987 Fibromyalgia was recognized by the American Medical Association as an illness and cause of disability
1987 The term fibromyalgia was used in the Journal of the American Medical Association.
1990 The American College of Rheumatology establishes guidelines for diagnosing fibromyalgia
Having Fibromyalgia can be frustrating because it is hard to diagnose and is often misunderstood. Unfortunately, doctors still don’t know what causes Fibromyalgia. And some refuse to recognize the disease because it can’t be diagnosed through x-rays and tests.The American College of Rheumatology has created guidelines to help assist physicians in diagnosing and studying the condition. However, not all doctors agree with the established guidelines for diagnosis. Some don’t recognize the disease while others think that the criteria are too strict.
Fibromyalgia is a combination of Greek words:
“Fibro,” meaning fiber
“My,” meaning muscle
“Algia,” meaning pain
History:
1800s Fibromyalgia was first described doctors. They called it muscular rheumatism.
1824 A doctor in Edinburgh described the “tender points” associated with Fibromyalgia
1880 Another doctor, describing the same condition, named it neurasthenia.
1904 An article referred to it as fibrositis. (“itis” means inflammation.)
1913 A physician named Luff noted that fibromyalgia symptoms changed as barometric pressure lowered as a storm approached.
1976 The term Fibromyalgia replaces the term fibrositis, recognizing that the condition is not caused by inflammation.
1987 Fibromyalgia was recognized by the American Medical Association as an illness and cause of disability
1987 The term fibromyalgia was used in the Journal of the American Medical Association.
1990 The American College of Rheumatology establishes guidelines for diagnosing fibromyalgia
Having Fibromyalgia can be frustrating because it is hard to diagnose and is often misunderstood. Unfortunately, doctors still don’t know what causes Fibromyalgia. And some refuse to recognize the disease because it can’t be diagnosed through x-rays and tests.The American College of Rheumatology has created guidelines to help assist physicians in diagnosing and studying the condition. However, not all doctors agree with the established guidelines for diagnosis. Some don’t recognize the disease while others think that the criteria are too strict.
Glutathione Deficiency Side Effect of Chronic Fatigue Syndrome
Though medical health professionals have yet to identify a specific cause of Chronic Fatigue Syndrome, they have been able to delineate several contributing factors that may lead to or exacerbate the condition. One of these factors appears to be a glutathione deficiency.
What is Glutathione?
Glutathione is a tripeptide that has many different functions to support a healthy body. The three amino acids that comprise glutathione are:
*Glycine
*Cysteine
*Gamma-glutamic acid
What does Glutathione do?
Glutathione serves the body in many important ways:
1. modulator of cellular homeostasis
2. detoxification of metals and oxyradicals
3. strong free radical scavenger, prevents damage to DNA and RNA
4. boost immune function
5. creates enzymes to assist the liver with detox
Click here to demonstrate to you why glutathione is so important to your health and well-being.
What is Glutathione?
Glutathione is a tripeptide that has many different functions to support a healthy body. The three amino acids that comprise glutathione are:
*Glycine
*Cysteine
*Gamma-glutamic acid
What does Glutathione do?
Glutathione serves the body in many important ways:
1. modulator of cellular homeostasis
2. detoxification of metals and oxyradicals
3. strong free radical scavenger, prevents damage to DNA and RNA
4. boost immune function
5. creates enzymes to assist the liver with detox
Click here to demonstrate to you why glutathione is so important to your health and well-being.
Sunday, January 6, 2008
Common symptoms of Diabetes
Symptoms:
*Unusual thirst
*Frequent urination
*Extreme fatigue and weakness
*Blurred vision
*Abdominal pains
*Nausea and vomiting
*Rapid weight loss or gain
*Skin infections
*Impotence
*Fluid retention (especially in legs and feet)
*Poor healing of skin wounds
*Decreased tolerance to cold
*Chronic itching
*Irregular or rapid heart rate
*Dry scaly skin
*Numbness or tingling of fingers and toes
*Extreme hunger pangs
*Hot and sweaty with clammy perspiration
*Heart tremors and palpitations
*Apprehensive with no obvious reason
*Shaky and nervous
*Disoriented, confused, inability to concentrate
*Frequent headaches, dizziness
*Mood changes, irritability
All diabetic symptoms are related to chronically high levels of glucose in the blood, which causes the premature aging of all body parts. So all diabetic symptoms can be explained in terms of what happens to the body as it ages. The branch of science that studies the aging process is called Gerontology and much of what happens to people with uncontrolled diabetes. more...
It is well known that aging is accompanied by a precipitous fall inglutathione levels. Lower glutathione levels are implicated in manydiseases associated with aging including cataracts, Alzheimer's,Parkinson's atherosclerosis and others.Journal of Clinical Epidemiology 47:1021-26, 1994.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
If you have any of the symptoms mentioned above, a family history of diabetes, or are aged 45 or above, contact your doctor or healthcare professional and initiate blood and urine tests for diabetes.
*Unusual thirst
*Frequent urination
*Extreme fatigue and weakness
*Blurred vision
*Abdominal pains
*Nausea and vomiting
*Rapid weight loss or gain
*Skin infections
*Impotence
*Fluid retention (especially in legs and feet)
*Poor healing of skin wounds
*Decreased tolerance to cold
*Chronic itching
*Irregular or rapid heart rate
*Dry scaly skin
*Numbness or tingling of fingers and toes
*Extreme hunger pangs
*Hot and sweaty with clammy perspiration
*Heart tremors and palpitations
*Apprehensive with no obvious reason
*Shaky and nervous
*Disoriented, confused, inability to concentrate
*Frequent headaches, dizziness
*Mood changes, irritability
All diabetic symptoms are related to chronically high levels of glucose in the blood, which causes the premature aging of all body parts. So all diabetic symptoms can be explained in terms of what happens to the body as it ages. The branch of science that studies the aging process is called Gerontology and much of what happens to people with uncontrolled diabetes. more...
It is well known that aging is accompanied by a precipitous fall inglutathione levels. Lower glutathione levels are implicated in manydiseases associated with aging including cataracts, Alzheimer's,Parkinson's atherosclerosis and others.Journal of Clinical Epidemiology 47:1021-26, 1994.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
If you have any of the symptoms mentioned above, a family history of diabetes, or are aged 45 or above, contact your doctor or healthcare professional and initiate blood and urine tests for diabetes.
Glutathione infusion potentiates glucose-induced insulin secretion in aged patients with impaired glucose tolerance
OBJECTIVE: To evaluate the effect of glutathione infusion on beta-cell response to glucose in elderly people with impaired glucose tolerance (IGT).
RESEARCH DESIGN AND METHODS: Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions and during 75-g oral glucose tolerance tests and intravenous glucose tolerance tests (0.33 g.kg body wt-1.3 min-1). Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
RESULTS:In subjects with normal glucose tolerance, glutathione infusion failed to affect beta-cell response to glucose. In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT. Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM. This effect disappeared at plasma glucose levels greater than 15 mM. No effect of glutathione on insulin clearance and action was observed.
CONCLUSIONS: Glutathione infusion enhances insulin secretion in elderly people with IGT.
G Paolisso, D Giugliano, G Pizza, A Gambardella, P Tesauro, M Varricchio and F D'Onofrio Institute of Geriatric Medicine, First Medical School; University of Naples, Italy.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
RESEARCH DESIGN AND METHODS: Ten patients with normal glucose tolerance and 10 patients with IGT were matched for age (mean +/- SE, 72.1 +/- 2.8 vs. 71.0 +/- 3.4 yr), body mass index (23.1 +/- 1.1 vs. 22 +/- 2.1 kg/m2), and sex (6/4 vs. 5/5, men/women) underwent glutathione infusion (10 mg/min) under basal conditions and during 75-g oral glucose tolerance tests and intravenous glucose tolerance tests (0.33 g.kg body wt-1.3 min-1). Patients with IGT were also submitted to euglycemic-hyperinsulemic and hyperglycemic glucose clamps.
RESULTS:In subjects with normal glucose tolerance, glutathione infusion failed to affect beta-cell response to glucose. In contrast, glutathione significantly potentiated glucose-induced insulin secretion in patients with IGT. Furthermore, in the latter group studied by hyperglycemic clamps, glutathione infusion significantly potentiated the beta-cell response to glucose when plasma glucose levels varied between 10 and 15 mM. This effect disappeared at plasma glucose levels greater than 15 mM. No effect of glutathione on insulin clearance and action was observed.
CONCLUSIONS: Glutathione infusion enhances insulin secretion in elderly people with IGT.
G Paolisso, D Giugliano, G Pizza, A Gambardella, P Tesauro, M Varricchio and F D'Onofrio Institute of Geriatric Medicine, First Medical School; University of Naples, Italy.
Click here to demonstrate to you why glutathione is so important to your health and well-being.
THE EFFECTS OF STREPTOZOTOCIN DIABETES AND DIETARY IRON INTAKE ON CATALASE
THE EFFECTS OF STREPTOZOTOCIN DIABETES AND DIETARY IRON INTAKE ON CATALASE, GLUTATHIONE PEROXIDASE, SUPEROXIDE DISMUTASE AND LIPID PEROXIDATION IN CARDIAC AND SKELETAL MUSCLES OF RATS
Abstract
Catalase, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) prevent oxygen free radical mediated tissue damage. Diabetes increases and a low dietary intake of iron decreases catalase activity in muscle. Therefore, the combined effects of diabetes and iron deficiency on the free radical scavenging enzyme system and lipid peroxidation were studied. Male, weanling rats were injected with streptozotocin (65 mg/kg, IV) and fed diets containing either 35 ppm iron (Db + Fe) or 8 ppm iron (Db $-$ Fe). Sham injected animals served as iron adequate (C + Fe) or iron deficient (C $-$ Fe) controls. Heart, gastrocnemius (GT), soleus and tibialis anterior (TA) muscles were dissected, weighted and analyzed for catalase, GSH-Px and SOD activities after 3, 6 or 9 weeks on the respective diets. The TBA assay was used to assess lipid peroxidation in the GT muscle. Diabetes elevated catalase activity in all muscles while it had a slight lowering effect on SOD and GSH-Px activities in the GT and TA muscles. In the C $-$ Fe rats, catalase activity declined and remained depressed in all muscles except the heart. There was an elevation in GSH-Px and SOD in the GT muscles of these animals after 6 weeks but not after 9 weeks of consuming the low iron diet. The Db $-$ Fe animals were unable to respond to the diabetic state with catalase activity as high as observed in the Db + Fe rats. Treatment with insulin or iron returned catalase to control levels. The C $-$ Fe animals had significantly lower levels of lipid peroxidation than the other groups at 6 and 9 weeks. Refeeding an iron adequate diet resulted in an increase in lipid peroxidation levels. These studies indicate that skeletal muscle free radical scavenging enzymes are sensitive to metabolic states and that dietary iron influences lipid peroxidation in this tissue.
SYDNEY REBECCA MORROW, THE UNIVERSITY OF TEXAS GRAD. SCH. OF BIOMED. SCI. AT HOUSTON Date: 1987
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Abstract
Catalase, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) prevent oxygen free radical mediated tissue damage. Diabetes increases and a low dietary intake of iron decreases catalase activity in muscle. Therefore, the combined effects of diabetes and iron deficiency on the free radical scavenging enzyme system and lipid peroxidation were studied. Male, weanling rats were injected with streptozotocin (65 mg/kg, IV) and fed diets containing either 35 ppm iron (Db + Fe) or 8 ppm iron (Db $-$ Fe). Sham injected animals served as iron adequate (C + Fe) or iron deficient (C $-$ Fe) controls. Heart, gastrocnemius (GT), soleus and tibialis anterior (TA) muscles were dissected, weighted and analyzed for catalase, GSH-Px and SOD activities after 3, 6 or 9 weeks on the respective diets. The TBA assay was used to assess lipid peroxidation in the GT muscle. Diabetes elevated catalase activity in all muscles while it had a slight lowering effect on SOD and GSH-Px activities in the GT and TA muscles. In the C $-$ Fe rats, catalase activity declined and remained depressed in all muscles except the heart. There was an elevation in GSH-Px and SOD in the GT muscles of these animals after 6 weeks but not after 9 weeks of consuming the low iron diet. The Db $-$ Fe animals were unable to respond to the diabetic state with catalase activity as high as observed in the Db + Fe rats. Treatment with insulin or iron returned catalase to control levels. The C $-$ Fe animals had significantly lower levels of lipid peroxidation than the other groups at 6 and 9 weeks. Refeeding an iron adequate diet resulted in an increase in lipid peroxidation levels. These studies indicate that skeletal muscle free radical scavenging enzymes are sensitive to metabolic states and that dietary iron influences lipid peroxidation in this tissue.
SYDNEY REBECCA MORROW, THE UNIVERSITY OF TEXAS GRAD. SCH. OF BIOMED. SCI. AT HOUSTON Date: 1987
Click here to demonstrate to you why glutathione is so important to your health and well-being
Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations
Hyperglycemia-induced embryonic malformations may be due to an increase in radical formation and depletion of intracellular glutathione (GSH) in embryonic tissues. In the past, we have investigated the role of the glutathione-dependent antioxidant system and GSH on diabetes-related embryonic malformations. Embryos from streptozotocin-induced diabetic rats on gestational day 11 showed a significantly higher frequency of embryonic malformations (neural lesions 21.5 vs. 2.8%, P<0.001; GSH in embryonic tissues of diabetic pregnant rats on day 11 was significantly lower than that of normal rats. The activity of y-glutamylcysteine synthetase (gamma-GCS), the rate-limiting GSH synthesizing enzyme, in embryos of diabetic rats was significantly low, associated with reduced expression of gamma-GCS mRNA. Administration of buthionine sulfoxamine (BSO), a specific inhibitor of gamma-GCS, to diabetic rats during the period of maximal teratogenic susceptibility (days 6-11 of gestation) reduced GSH by 46.7% and increased the frequency of neural lesions (62.1 vs. 21.5%, P<0.01) GSH ester to diabetic rats restored GSH concentration in the embryos and reduced the formation of ROS, leading to normalization of neural lesions (1.9 vs. 21.5%) and improvement in nonneural lesions (26.7 vs. 47.4%) and growth retardation. Administration of insulin in another group of pregnant rats during the same period resulted in complete normalization of neural lesions (4.3 vs. 21.5%), nonneural lesions (4.3 vs. 47.4%), and growth retardation with the restoration of GSH contents. Our results indicate that GSH depletion and impaired responsiveness of GSH-synthesizing enzyme to oxidative stress during organogenesis may have important roles in the development of embryonic malformations in diabetes.
Click here to demonstrate to you why Glutathione is so important to your health and well-being
Click here to demonstrate to you why Glutathione is so important to your health and well-being
Abnormalities of retinal metabolism in diabetes or galactosemia
PURPOSE: Experimental galactosemia and diabetes are known to result in diabetic-like retinopathy in animals, but the mechanism by which the retinopathy develops remains unclear.
Defects of retinal metabolism that are common to galactosemia and diabetes are closely associated with the development of retinopathy and might play a role in the pathogenesis of the retinal disease.
METHODS: Effects of experimental galactosemia on retinal calcium-activated ATPase [(Ca,Mg)-ATPase], sodium-potassium ATPase [(Na,K)-ATPase], glutathione, ATP, and pertinent ions have been compared with the effects of experimental diabetes in rat and dog models of diabetic retinopathy.
RESULTS: Activities of (Ca,Mg)-ATPase and (Na,K)-ATPase were decreased as a result of either experimental galactosemia or diabetes in both the dog and the rat, and the decreases were accompanied by a diminution of reduced glutathione (GSH) in the retina. Ouabain-insensitive ATPase activity in the retina was not significantly reduced by diabetes or galactosemia, suggesting that the observed defects in (Ca,Mg)-ATPase and (Na,K)-ATPase activities were specific. The decrease of retinal GSH levels was associated with an elevated concentration of oxidized glutathione in diabetes but not in galactosemia. Retinal ATP and ion concentrations remained unaffected by experimental galactosemia or diabetes.
CONCLUSIONS: Comparison of two etiologically dissimilar models of diabetic retinopathy (diabetes and galactosemia) has revealed abnormalities of retinal metabolism that are shared by the two models. Further comparisons of retinal metabolism between these two models should reveal additional sequelae of hyperglycemia that are associated with, and that might play a role in, the development of diabetic retinopathy.
TS Kern, RA Kowluru and RL Engerman Department of Ophthalmology and Visual Science, University of Wisconsin- Madison 53706-1532.
Investigative Ophthalmology & Visual Science, Vol 35, 2962-2967, Copyright © 1994 by Association for Research in Vision and Ophthalmology
Defects of retinal metabolism that are common to galactosemia and diabetes are closely associated with the development of retinopathy and might play a role in the pathogenesis of the retinal disease.
METHODS: Effects of experimental galactosemia on retinal calcium-activated ATPase [(Ca,Mg)-ATPase], sodium-potassium ATPase [(Na,K)-ATPase], glutathione, ATP, and pertinent ions have been compared with the effects of experimental diabetes in rat and dog models of diabetic retinopathy.
RESULTS: Activities of (Ca,Mg)-ATPase and (Na,K)-ATPase were decreased as a result of either experimental galactosemia or diabetes in both the dog and the rat, and the decreases were accompanied by a diminution of reduced glutathione (GSH) in the retina. Ouabain-insensitive ATPase activity in the retina was not significantly reduced by diabetes or galactosemia, suggesting that the observed defects in (Ca,Mg)-ATPase and (Na,K)-ATPase activities were specific. The decrease of retinal GSH levels was associated with an elevated concentration of oxidized glutathione in diabetes but not in galactosemia. Retinal ATP and ion concentrations remained unaffected by experimental galactosemia or diabetes.
CONCLUSIONS: Comparison of two etiologically dissimilar models of diabetic retinopathy (diabetes and galactosemia) has revealed abnormalities of retinal metabolism that are shared by the two models. Further comparisons of retinal metabolism between these two models should reveal additional sequelae of hyperglycemia that are associated with, and that might play a role in, the development of diabetic retinopathy.
TS Kern, RA Kowluru and RL Engerman Department of Ophthalmology and Visual Science, University of Wisconsin- Madison 53706-1532.
Investigative Ophthalmology & Visual Science, Vol 35, 2962-2967, Copyright © 1994 by Association for Research in Vision and Ophthalmology
Oxidative Stress and Glutathione Synthesis in Type 2 Diabetes: a Stable Isotope Approach
Many of the complications of diabetes are linked to oxidative damage.
We set out to determine whether the reduced antioxidant capacity (as reflected by glutathione concentration) in type diabetes is due to reduced synthesis or increased consumption of glutathione(GSH), and whether short-term dietary supplementation with glycine and cysteine, precursors of GSH, would improve oxidant status.
2H2-glycine was infused for 7 hours to measure glycine kinetics and red blood cell GSH (RBC-GSH) synthesis in diabetic and euglycemic subjects. These same measurements were repeated in a subset of diabetic subjects after 2 weeks of supplementation with glycine and cysteine, the precursors of glutathione. Lipid hydroperoxide and lymphocyte glutathione concentration were also measured.
Twenty euglycemic subjects and 10 subjects with type 2 diabetes participated in the unsupplemented study.
Authors
Reeds, Peter
Jahoor, Farook
Siripoom, Mckay - BAYLOR COLLEGE/MEDICINE
Morlese, John - UNIV. WEST INDIES
Forrester, Terrence - UNIV. WEST INDIES
Jackson, Alan - ROYAL COLLEGE/PHYSICIANTS
Balasubramanyan, Ashok - BAYLOR COLLEGE/ MEDICINE
We set out to determine whether the reduced antioxidant capacity (as reflected by glutathione concentration) in type diabetes is due to reduced synthesis or increased consumption of glutathione(GSH), and whether short-term dietary supplementation with glycine and cysteine, precursors of GSH, would improve oxidant status.
2H2-glycine was infused for 7 hours to measure glycine kinetics and red blood cell GSH (RBC-GSH) synthesis in diabetic and euglycemic subjects. These same measurements were repeated in a subset of diabetic subjects after 2 weeks of supplementation with glycine and cysteine, the precursors of glutathione. Lipid hydroperoxide and lymphocyte glutathione concentration were also measured.
Twenty euglycemic subjects and 10 subjects with type 2 diabetes participated in the unsupplemented study.
Authors
Reeds, Peter
Jahoor, Farook
Siripoom, Mckay - BAYLOR COLLEGE/MEDICINE
Morlese, John - UNIV. WEST INDIES
Forrester, Terrence - UNIV. WEST INDIES
Jackson, Alan - ROYAL COLLEGE/PHYSICIANTS
Balasubramanyan, Ashok - BAYLOR COLLEGE/ MEDICINE
Hepatic Glutathione Metabolism in Diabetes
Glutathione is important in the regulation of the redox state, and a decline in its tissue level has often been considered to be indicative of increased oxidative stress in diabetes.
In this study of diabetic rats, the level of hepatic glutathione was normal unless food intake was restricted.
Thus, the previous report of a reduction in hepatic glutathione in diabetes is likely to be the result of food deprivation rather than diabetes alone. In contrast to changes characteristic of oxidative stress, the efflux of glutathione in bile from diabetic animals was significantly decreased, whereas hepatic mixed disulfides were unchanged, and the hepatic gamma-glutamyltransferase activity was considerably increased.
These changes were not reproduced by food deprivation. The decrease in biliary excretion of glutathione in diabetes may reflect an attempt to conserve glutathione by activation of the hepatic gamma-glutamyl cycle. We conclude that the disturbances of glutathione metabolism in diabetes are not typical of those seen in oxidative stress or food restriction.
Click here to demonstrate to you why Glutathione is so important to your health and well-being.
Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
In this study of diabetic rats, the level of hepatic glutathione was normal unless food intake was restricted.
Thus, the previous report of a reduction in hepatic glutathione in diabetes is likely to be the result of food deprivation rather than diabetes alone. In contrast to changes characteristic of oxidative stress, the efflux of glutathione in bile from diabetic animals was significantly decreased, whereas hepatic mixed disulfides were unchanged, and the hepatic gamma-glutamyltransferase activity was considerably increased.
These changes were not reproduced by food deprivation. The decrease in biliary excretion of glutathione in diabetes may reflect an attempt to conserve glutathione by activation of the hepatic gamma-glutamyl cycle. We conclude that the disturbances of glutathione metabolism in diabetes are not typical of those seen in oxidative stress or food restriction.
Click here to demonstrate to you why Glutathione is so important to your health and well-being.
Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
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