The proliferation of T and B cells, natural killer cells, and lymphokine activated killer cells that are required to mount an effective defense against pathogens and tumor cells appear to be inhibited markedly with age and upon exposure to oxidants. These effects can, in part, be counteracted in elderly individuals by dietary antioxidant supplementation. While the endogenous sources of oxidants that lead to the suppression of lymphocyte dependent immunity are not known, in vitro studies have demonstrated that polymorphonuclear leucocytes and macrophages, both can inhibit proliferation of various lymphocyte subpopulations through the production of reactive oxygen intermediates and the prostaglandin metabolite PGE2 as well as from nitric oxide.
This suggests that conditions that involve infiltration of polymorphonuclear leucocytes and macrophages (i.e., chronic inflammatory diseases), could result in compromised lymphocyte function. The suppressive effects of macrophages on mitogen induced lymphocyte proliferation can be reversed partially by thiol reagents, catalase or indomethacin, or by NG-monomethyl-L-arginine, a competitive inhibitor of nitric oxide synthesis.
The age associated decrease in cell mediated immunity may be due to a decreased level of certain small molecule antioxidant and antioxidant enzymes that accompany the aging process.
Calorie restriction, a dietary regimen that increases maximal lifespan in rodents also enhances T lymphocyte responsiveness possibly by slowing the rate of thymus involution and by boosting the level of cellular antioxidant defenses.
Showing posts with label Immune system. Show all posts
Showing posts with label Immune system. Show all posts
Monday, February 11, 2008
Thursday, February 7, 2008
Oxidants, Antioxidants, and the Degenerative Diseases of Aging
Metabolism, like other aspects of life, involves trade-offs. Oxidant by-products of normal metabolism cause extensive damage to DNA, protein, and lipid. We argue that this damage (the same as that produced by radiation) is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune system decline, brain dysfunction and cataracts. Antioxidant defenses against this damage include ascorbate, tocopherol and carotenoids. Fruits and vegetables are the principal source of ascorbate and carotenoids and are one source of tocopherol. Low dietary intake of fruits and vegetables doubles the risk of most types of cancer as compared to high intake and also markedly increases the risk of heart disease and cataracts. Since only 9% of Americans eat the recommended five servings of fruits and vegetables per day the opportunity for improving health by improving diet is great.
The degenerative diseases associated with aging include cancer, cardiovascular disease, immune system decline, brain dysfunction, and cataracts. The functional degeneration of somatic cells during aging appears, in good part, to contribute to these diseases. The relationship between cancer and age in various mammalian species illustrates this point. Cancer increases with about the fifth power of age in both short-lived species, such as rats, and in long-lived species, such as humans.
Thus a marked decrease in age-specific cancer rates has accompanied the marked increase in life span that has occurred in 60 million years of mammalian evolution: i.e., cancer rates are high in a two year old rat, but low in a two year old human. One important factor in longevity appears to be basal metabolic rate, which is about seven times higher in a rat than a human and which could markedly affect the level of endogenous oxidants and other mutagens produced as by-products of metabolism. The level of oxidative DNA damage appears to be roughly related to metabolic rate in a number of mammalian species (cancer/mutation/endogenous DNA adducts/oxygen radicals)
Click here for more about Glutathione and its benefits to our body.
By Bruce N. Ames*, Mark K. Shigenaga, and Tory M. Hagen
The degenerative diseases associated with aging include cancer, cardiovascular disease, immune system decline, brain dysfunction, and cataracts. The functional degeneration of somatic cells during aging appears, in good part, to contribute to these diseases. The relationship between cancer and age in various mammalian species illustrates this point. Cancer increases with about the fifth power of age in both short-lived species, such as rats, and in long-lived species, such as humans.
Thus a marked decrease in age-specific cancer rates has accompanied the marked increase in life span that has occurred in 60 million years of mammalian evolution: i.e., cancer rates are high in a two year old rat, but low in a two year old human. One important factor in longevity appears to be basal metabolic rate, which is about seven times higher in a rat than a human and which could markedly affect the level of endogenous oxidants and other mutagens produced as by-products of metabolism. The level of oxidative DNA damage appears to be roughly related to metabolic rate in a number of mammalian species (cancer/mutation/endogenous DNA adducts/oxygen radicals)
Click here for more about Glutathione and its benefits to our body.
By Bruce N. Ames*, Mark K. Shigenaga, and Tory M. Hagen
Glutathione helps to support the proper functioning
Glutathione helps to support the proper functioning of your immune system , and will improve immune system already in retreat.
Glutathione acts as an powerful antioxidant and Free radicals scavenger, thereby protecting our DNA and RDA from damage due to many environmental factors.
Glutathione acts as the regulator of other powerful antioxidant.
Glutathione acts as a detoxifying agent, removing foreign objects, chemicals and toxins from the body. As you age, your levels of Glutathione are depleted, thereby allowing the aging process to accelerate.
Levels of Glutathione can be sucessfully improved by taking a high quality nutritional supplement!
***Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
http://www.healthline.com/galecontent/glutathione
Click here for more about Glutathione and its benefits to our body.
Glutathione acts as an powerful antioxidant and Free radicals scavenger, thereby protecting our DNA and RDA from damage due to many environmental factors.
Glutathione acts as the regulator of other powerful antioxidant.
Glutathione acts as a detoxifying agent, removing foreign objects, chemicals and toxins from the body. As you age, your levels of Glutathione are depleted, thereby allowing the aging process to accelerate.
Levels of Glutathione can be sucessfully improved by taking a high quality nutritional supplement!
***Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
http://www.healthline.com/galecontent/glutathione
Click here for more about Glutathione and its benefits to our body.
Cysteine, Glutamic Acid and Glycine- immune system
Glutathione is a tri-peptide composed of three amino acids: Cysteine, Glutamic Acid and Glycine.
Glutathione and the enzymes it forms, such as GTH peroxidase, are essential to all life and are found in tissues of virtually all plants and animals. GTH is present in all human cells, with the highest levels found in the liver, the lenses of the eyes, pancreas, spleen and kidneys.
Glutathione acts as a powerful antioxidant, a key protector against all types of pollution and is effective in preventing aging. It protects DNA and RNA from free-radical damage.
Glutathione also protects against cellular peroxidation caused by exposure to pesticides, plastics, benzene and carbon tetrachloride, as well as heavy metals, cigarette smoke, smog, drugs, solvents, dyes, phenols and nitrates.
Glutathione works to inhibit the formation of free radicals, dangerous agents that suppress the immune system and promote the formation of mutagens and carcinogens.
Free radicals also speed up the aging process, and it is due to this powerful antioxidant activity that Glutathione is considered useful in the prevention and treatment of a wide range of degenerative diseases.
Studies at the Louisville School of Medicine have clearly shown that Glutathione possesses the unique ability to slow the aging process. While Glutathione aids in the protection of all cells and membranes, a study at Harvard Medical School found that Glutathione is especially able to enhance immune system cells, protecting against damage from radiation and helping to reduce the side effects of chemotherapy and x-rays and alcohol. As a detoxifier of metals and drugs, Glutathione also aids in the treatment of blood and liver disorders.
As individuals grow older, Glutathione levels drop, and the ability to detoxify free radicals decreases.
It can protect against cadmium, copper, and acetaminophen (the active agent in Tylenol) toxicity. Glutathione aids the liver in detoxification, slows the aging process, helps the cardiovascular and immune system, and is helpful in preventing or treating many other health conditions.
Supplementation may prevent, or be helpful with, the following conditions:
Aging
Alcoholism
Asthma
Atherosclerosis (heart disease)
Cancer
Cataracts
Dizziness
Hepatitis
Immunodepression (immune function)
Infertility (male)
Memory Loss (Alzheimer's disease, dementia)
Osteoarthritis
Parkinson's Disease
Peptic Ulcers
Click here for more about Glutathione and its benefits to our body.
Glutathione and the enzymes it forms, such as GTH peroxidase, are essential to all life and are found in tissues of virtually all plants and animals. GTH is present in all human cells, with the highest levels found in the liver, the lenses of the eyes, pancreas, spleen and kidneys.
Glutathione acts as a powerful antioxidant, a key protector against all types of pollution and is effective in preventing aging. It protects DNA and RNA from free-radical damage.
Glutathione also protects against cellular peroxidation caused by exposure to pesticides, plastics, benzene and carbon tetrachloride, as well as heavy metals, cigarette smoke, smog, drugs, solvents, dyes, phenols and nitrates.
Glutathione works to inhibit the formation of free radicals, dangerous agents that suppress the immune system and promote the formation of mutagens and carcinogens.
Free radicals also speed up the aging process, and it is due to this powerful antioxidant activity that Glutathione is considered useful in the prevention and treatment of a wide range of degenerative diseases.
Studies at the Louisville School of Medicine have clearly shown that Glutathione possesses the unique ability to slow the aging process. While Glutathione aids in the protection of all cells and membranes, a study at Harvard Medical School found that Glutathione is especially able to enhance immune system cells, protecting against damage from radiation and helping to reduce the side effects of chemotherapy and x-rays and alcohol. As a detoxifier of metals and drugs, Glutathione also aids in the treatment of blood and liver disorders.
As individuals grow older, Glutathione levels drop, and the ability to detoxify free radicals decreases.
It can protect against cadmium, copper, and acetaminophen (the active agent in Tylenol) toxicity. Glutathione aids the liver in detoxification, slows the aging process, helps the cardiovascular and immune system, and is helpful in preventing or treating many other health conditions.
Supplementation may prevent, or be helpful with, the following conditions:
Aging
Alcoholism
Asthma
Atherosclerosis (heart disease)
Cancer
Cataracts
Dizziness
Hepatitis
Immunodepression (immune function)
Infertility (male)
Memory Loss (Alzheimer's disease, dementia)
Osteoarthritis
Parkinson's Disease
Peptic Ulcers
Click here for more about Glutathione and its benefits to our body.
Wednesday, February 6, 2008
Inflammation, Free Radicals, and Cytokines
Although acute Inflammation is an important immune system response, chronic inflammation has also been linked to many diseases, including heart disease. Besides the pro-Inflammation cytokines, Inflammation may be related to the overproduction of free radicals (Janeway CA et al 1999).
A free radical is an atom or group of atoms (i.e., a molecule) with unpaired electrons. Free radicals are extremely unstable and react easily with other molecules, thereby changing their chemical composition. Oxygen is especially susceptible to free radical formation. The free radicals derived from oxygen are known as reactive oxygen species, or oxidants.
When the body has increased levels of reactive oxygen species (i.e., when it is experiencing oxidative stress), widespread damage may result. At high concentrations free radicals can damage fats, proteins, and nucleic acids. They can also cause cell death, gene mutations, and cancer ( Moslen MT 1994). Several diseases may be the result of cellular and genetic damage caused by free radicals, including several immune disorders ( Moslen MT 1994).
In order to reduce the damage caused by elevated free radicals and cytokines (which are both part of the natural immune system), the body fights back by producing antioxidants and hormones such as cortisol to suppress the immune system (Grimble RF 1996). Antioxidants are valuable because they pair with unstable free radicals, thereby limiting the damage free radicals can inflict on other cells.
Click here for more about Glutathione and its benefits to our body.
A free radical is an atom or group of atoms (i.e., a molecule) with unpaired electrons. Free radicals are extremely unstable and react easily with other molecules, thereby changing their chemical composition. Oxygen is especially susceptible to free radical formation. The free radicals derived from oxygen are known as reactive oxygen species, or oxidants.
When the body has increased levels of reactive oxygen species (i.e., when it is experiencing oxidative stress), widespread damage may result. At high concentrations free radicals can damage fats, proteins, and nucleic acids. They can also cause cell death, gene mutations, and cancer ( Moslen MT 1994). Several diseases may be the result of cellular and genetic damage caused by free radicals, including several immune disorders ( Moslen MT 1994).
In order to reduce the damage caused by elevated free radicals and cytokines (which are both part of the natural immune system), the body fights back by producing antioxidants and hormones such as cortisol to suppress the immune system (Grimble RF 1996). Antioxidants are valuable because they pair with unstable free radicals, thereby limiting the damage free radicals can inflict on other cells.
Click here for more about Glutathione and its benefits to our body.
Phagocytic cells
Phagocytic cells engulf foreign cells and destroy them. The phagocytic cells are white blood cells and include neutrophils, eosinophils, and macrophages; they have short lives and must be continually replenished by the body. Neutrophils and macrophages are a very important aspect of the innate defenses of the body (Janeway CA et al 1999; Beers MB 2004).
Click here for more information about Glutathione and its benefits in our immune system.
More study:
Polymorphonuclear leukocytes isolated from chicken peritoneal exudates have been found to catalyze cyanide-insensitive stimulation of respiration and the hexose monophosphate shunt upon exposure to heat-inactivated Staphylococcus aureus.
However, there was no demonstrable formate oxidation concomitant with phagocytosis in either the presence or absence of exogenous catalase. Moreover, chicken polymorphonuclear leukocytes failed to oxidize scopoletin concomitant with phagocytosis in the presence of horseradish peroxidase. While oxygen uptake was increased 2- to 3-fold by the stimulus of phagocytosis, the oxidation of [1-(14)C]glucose was increased approximately 20-fold.
The cells contain two mechanisms, a Glutathione reductase-Glutathione peroxidase system and an NADPH-NAD+ transhydrogenase, each of which is present in sufficient capacity to accommodate the enhanced shunt activity.
Although chicken polymorphonuclear leukocytes were found to possess a substantial capacity to catalyze the cyanide-insensitive oxidation of either NADH or NADPH, the total or specific activities of such processes were not demonstrably affected by phagocytosis.
Click here for more information about Glutathione and its benefits in our immune system.
Click here for more information about Glutathione and its benefits in our immune system.
More study:
Polymorphonuclear leukocytes isolated from chicken peritoneal exudates have been found to catalyze cyanide-insensitive stimulation of respiration and the hexose monophosphate shunt upon exposure to heat-inactivated Staphylococcus aureus.
However, there was no demonstrable formate oxidation concomitant with phagocytosis in either the presence or absence of exogenous catalase. Moreover, chicken polymorphonuclear leukocytes failed to oxidize scopoletin concomitant with phagocytosis in the presence of horseradish peroxidase. While oxygen uptake was increased 2- to 3-fold by the stimulus of phagocytosis, the oxidation of [1-(14)C]glucose was increased approximately 20-fold.
The cells contain two mechanisms, a Glutathione reductase-Glutathione peroxidase system and an NADPH-NAD+ transhydrogenase, each of which is present in sufficient capacity to accommodate the enhanced shunt activity.
Although chicken polymorphonuclear leukocytes were found to possess a substantial capacity to catalyze the cyanide-insensitive oxidation of either NADH or NADPH, the total or specific activities of such processes were not demonstrably affected by phagocytosis.
Click here for more information about Glutathione and its benefits in our immune system.
Inflammation and fever
Inflammation is a nonspecific response to infection or tissue injury. The four signs of the inflammatory response are redness, swelling, heat, and pain.
Inflammation begins when cells release certain cytokines, including interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-alpha ) (Janeway CA et al 1999; Beers MB 2004).
Inflammation is a process by which the body’s white blood cells and chemicals protect us from infection and foreign substances such as bacteria and viruses.
In some diseases, however, the body’s defense system (immune system) inappropriately triggers an Inflammation response when there are no foreign substances to fight off. In these diseases, called autoimmune diseases, the body’s normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal.
Click here for more information about Glutathione and its benefits in our immune system.
Inflammation begins when cells release certain cytokines, including interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-alpha ) (Janeway CA et al 1999; Beers MB 2004).
Inflammation is a process by which the body’s white blood cells and chemicals protect us from infection and foreign substances such as bacteria and viruses.
In some diseases, however, the body’s defense system (immune system) inappropriately triggers an Inflammation response when there are no foreign substances to fight off. In these diseases, called autoimmune diseases, the body’s normally protective immune system causes damage to its own tissues. The body responds as if normal tissues are infected or somehow abnormal.
Click here for more information about Glutathione and its benefits in our immune system.
Physical and chemical barriers
The body's first lines of defense are the skin and mucous membranes, which prevent the entrance of many pathogens.
There are many secondary barriers.
For example, tears, sweat, and saliva combat some bacteria, and the hydrochloric acid and protein-digesting enzymes secreted by the stomach are lethal to many, but not all, pathogens (Janeway CA et al 1999; Beers MB 2004).
Click here for more information about Glutathione and its benefits in our immune system.
THE MAX GXL is a PATENTED High Performance Formula which:Dramatically Raises Your Energy LevelSlows Down The Aging ProcessStrengthens Your Immune SystemFights Inflammation and Diseases of AgingImproves Athletic Performance & RecoveryDetoxify Your Body
There are many secondary barriers.
For example, tears, sweat, and saliva combat some bacteria, and the hydrochloric acid and protein-digesting enzymes secreted by the stomach are lethal to many, but not all, pathogens (Janeway CA et al 1999; Beers MB 2004).
Click here for more information about Glutathione and its benefits in our immune system.
THE MAX GXL is a PATENTED High Performance Formula which:Dramatically Raises Your Energy LevelSlows Down The Aging ProcessStrengthens Your Immune SystemFights Inflammation and Diseases of AgingImproves Athletic Performance & RecoveryDetoxify Your Body
The Immune System
The immune system is an elegant and complex set of components that combine to fight disease, infections, and various pathogens. A healthy immune system distinguishes organisms in the body as “self” or “non-self.” An intact immune response identifies pathogens as “non-self” and rapidly destroys them. A depressed immune system, by contrast, will allow invading organisms to flourish.
Furthermore, when the immune system mistakenly recognizes a “self” cell as “non-self” and mounts an immune response, the result is an autoimmune disorder such as rheumatoid arthritis.
In general, the body has two primary defense mechanisms: natural immunity and acquired immunity. Natural immunity is the “first responder” to an attack. The natural immune response relies on various white blood cells and physical barriers to block or immediately attack any foreign invader and attempt to destroy it.
Acquired immunity, on the other hand, involves antibodies that are created in response to specific foreign antigens. This sort of response requires a few days for the body to recognize the invader and manufacture antibodies against it. Once the body has manufactured a particular antibody for a specific invader, the immune system response is faster and more effective the next time that invader appears (Janeway CA et al 1999; Beers MB 2004).
Click here for more information about Glutathione and its benefits in our immune system.
Furthermore, when the immune system mistakenly recognizes a “self” cell as “non-self” and mounts an immune response, the result is an autoimmune disorder such as rheumatoid arthritis.
In general, the body has two primary defense mechanisms: natural immunity and acquired immunity. Natural immunity is the “first responder” to an attack. The natural immune response relies on various white blood cells and physical barriers to block or immediately attack any foreign invader and attempt to destroy it.
Acquired immunity, on the other hand, involves antibodies that are created in response to specific foreign antigens. This sort of response requires a few days for the body to recognize the invader and manufacture antibodies against it. Once the body has manufactured a particular antibody for a specific invader, the immune system response is faster and more effective the next time that invader appears (Janeway CA et al 1999; Beers MB 2004).
Click here for more information about Glutathione and its benefits in our immune system.
Raised Glutathione Levels Help Balance Immune System
Researchers from Germany and the US have found that Glutathione can boost the natural antioxidant system of the body.
The body carries many antioxidant defense systems, but inside cells a small protein called glutathione is crucial. Glutathione is essential for the function of immune cells, which protect us from viral and bacterial infections.
In people with immune deficiency, glutathione levels fall well below the normal levels in blood and immune cells. Restoring glutathione levels to those found in healthy people is likely to help immune deficient patients.
Two studies have recently been published with research backing up the claims that Glutathione helps fight disease, one in the European Journal of Clinical Investigation, from Stig Froland in Oslo, Norway, and the other by Leonore and Leonard Herzenberg, a husband and wife team from Stanford, California. The results of their work showed that glutathione levels could indeed be restored in AIDS patients and that this may improve the outlook for these patients.
Herzenberg and colleagues conducted a clinical trial in which 31 HIV-infected patients were given daily doses of Glutathione — and 30 others were given a benign sugar pill. According to the study published in the October 1 issue of the European Journal of Clinical Investigation, those taking Glutathione had increased the amount of glutathione in their bodies to near-normal levels at the end of the two-month trial.
“The importance here is that glutathione is a central component of all cells, and glutathione deficiency is associated with poor prognosis in many, many diseases,” said Herzenberg. “What we’ve proven is that giving people Glutathione replenishes the glutathione stores.”
The authors of the report concluded that “Glutathione offers useful adjunct therapy to increase protection against oxidative stress, improve immune system function and increase detoxification of acetaminophen and other drugs. These findings suggest Glutathione therapy could be valuable in other clinical situations in which there is GSH deficiency.”
“It is important to realize that these results are the culmination of over 10 years of research.” states Frank Staal, an immunologist from Rotterdam, The Netherlands, who worked in this field for many years. “The groups of Droge and Herzenberg were the first to demonstrate that Glutathione is low in AIDS and that this defect contributes to poor immune cell function." ImmuneSupport.com
Click here for more about Glutathione and its benefits to our body.
The body carries many antioxidant defense systems, but inside cells a small protein called glutathione is crucial. Glutathione is essential for the function of immune cells, which protect us from viral and bacterial infections.
In people with immune deficiency, glutathione levels fall well below the normal levels in blood and immune cells. Restoring glutathione levels to those found in healthy people is likely to help immune deficient patients.
Two studies have recently been published with research backing up the claims that Glutathione helps fight disease, one in the European Journal of Clinical Investigation, from Stig Froland in Oslo, Norway, and the other by Leonore and Leonard Herzenberg, a husband and wife team from Stanford, California. The results of their work showed that glutathione levels could indeed be restored in AIDS patients and that this may improve the outlook for these patients.
Herzenberg and colleagues conducted a clinical trial in which 31 HIV-infected patients were given daily doses of Glutathione — and 30 others were given a benign sugar pill. According to the study published in the October 1 issue of the European Journal of Clinical Investigation, those taking Glutathione had increased the amount of glutathione in their bodies to near-normal levels at the end of the two-month trial.
“The importance here is that glutathione is a central component of all cells, and glutathione deficiency is associated with poor prognosis in many, many diseases,” said Herzenberg. “What we’ve proven is that giving people Glutathione replenishes the glutathione stores.”
The authors of the report concluded that “Glutathione offers useful adjunct therapy to increase protection against oxidative stress, improve immune system function and increase detoxification of acetaminophen and other drugs. These findings suggest Glutathione therapy could be valuable in other clinical situations in which there is GSH deficiency.”
“It is important to realize that these results are the culmination of over 10 years of research.” states Frank Staal, an immunologist from Rotterdam, The Netherlands, who worked in this field for many years. “The groups of Droge and Herzenberg were the first to demonstrate that Glutathione is low in AIDS and that this defect contributes to poor immune cell function." ImmuneSupport.com
Click here for more about Glutathione and its benefits to our body.
Wednesday, January 23, 2008
Selenium
Selenium is a co-factor for the enzyme glutathione peroxidase.
Selenium supplements have become popular because some studies suggest they may play a role in decreasing the risk of certain cancers, and in how the immune system and the thyroid gland function.
However, too much selenium can cause some toxic effects including gastrointestinal upset, brittle nails, hair loss and mild nerve damage.
Click here for more about Glutathione and its benefits to our body.
Consult your health professional before taking any kind of medicines.
Glutathione Strenthens your immune system
Lymphocytes, cells vital for your immune system , depend on Glutathione for their proper function and replication.IMMUNOLOGY 61: 503-508 1987
Selenium supplements have become popular because some studies suggest they may play a role in decreasing the risk of certain cancers, and in how the immune system and the thyroid gland function.
However, too much selenium can cause some toxic effects including gastrointestinal upset, brittle nails, hair loss and mild nerve damage.
Click here for more about Glutathione and its benefits to our body.
Consult your health professional before taking any kind of medicines.
Glutathione Strenthens your immune system
Lymphocytes, cells vital for your immune system , depend on Glutathione for their proper function and replication.IMMUNOLOGY 61: 503-508 1987
N-Acetyl-Cysteine (NAC)
Food sources and dietary supplements that help boost glutathione levels naturally.
N-Acetyl-Cysteine (NAC)
It is derived from the amino acid L-Cysteine, and acts as a precursor of glutathione.
NAC is quickly metabolized into glutathione once it enters the body.
It has been proven in numerous scientific studies and clinical trials, to boost intracellular production of glutathione, and is approved by the FDA for treatment of accetaminophen overdose.
Because of glutathione mucolytic action, NAC is commonly used in the treatment of lung diseases like cystic fibrosis, bronchitis and asthma.
Click here for more about Glutathione and its benefits to our body.
N-Acetyl-Cysteine (NAC)
It is derived from the amino acid L-Cysteine, and acts as a precursor of glutathione.
NAC is quickly metabolized into glutathione once it enters the body.
It has been proven in numerous scientific studies and clinical trials, to boost intracellular production of glutathione, and is approved by the FDA for treatment of accetaminophen overdose.
Because of glutathione mucolytic action, NAC is commonly used in the treatment of lung diseases like cystic fibrosis, bronchitis and asthma.
Click here for more about Glutathione and its benefits to our body.
Tuesday, January 22, 2008
Exercise builds brain health: key roles of growth factor cascades and inflammation
Human and other animal studies demonstrate that exercise targets many aspects of brain function and has broad effects on overall brain health.
The benefits of exercise have been best defined for learning and memory, protection from neurodegeneration and alleviation of depression, particularly in elderly populations.
Exercise increases synaptic plasticity by directly affecting synaptic structure and potentiating synaptic strength, and by strengthening the underlying systems that support plasticity including neurogenesis, metabolism and vascular function.
Such exercise-induced structural and functional change has been documented in various brain regions but has been best-studied in the hippocampus - the focus of this review.
A key mechanism mediating these broad benefits of exercise on the brain is induction of central and peripheral growth factors and growth factor cascades, which instruct downstream structural and functional change.
In addition, exercise reduces peripheral risk factors such as diabetes, hypertension and cardiovascular disease, which converge to cause brain dysfunction and neurodegeneration.
A common mechanism underlying the central and peripheral effects of exercise might be related to inflammation, which can impair growth factor signaling both systemically and in the brain.
Thus, through regulation of growth factors and reduction of peripheral and central risk factors, exercise ensures successful brain function.
by: Carl W Cotman, Nicole C Berchtold, Lori-Ann Christie
Trends in Neurosciences, Vol. 30, No. 9. (September 2007), pp. 464-472
Important Roles of Glutathione
Fight against oxidative cell damage (Free Radicals)
• Protein Synthesis
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
• Fight Inflammation
• ATP (energy) production
Our cells are constantly under attack by Free Radicals, which can cause a reduction of our cells ability to function optimally.
Click here for more about Glutathione and its benefits to our body.
The benefits of exercise have been best defined for learning and memory, protection from neurodegeneration and alleviation of depression, particularly in elderly populations.
Exercise increases synaptic plasticity by directly affecting synaptic structure and potentiating synaptic strength, and by strengthening the underlying systems that support plasticity including neurogenesis, metabolism and vascular function.
Such exercise-induced structural and functional change has been documented in various brain regions but has been best-studied in the hippocampus - the focus of this review.
A key mechanism mediating these broad benefits of exercise on the brain is induction of central and peripheral growth factors and growth factor cascades, which instruct downstream structural and functional change.
In addition, exercise reduces peripheral risk factors such as diabetes, hypertension and cardiovascular disease, which converge to cause brain dysfunction and neurodegeneration.
A common mechanism underlying the central and peripheral effects of exercise might be related to inflammation, which can impair growth factor signaling both systemically and in the brain.
Thus, through regulation of growth factors and reduction of peripheral and central risk factors, exercise ensures successful brain function.
by: Carl W Cotman, Nicole C Berchtold, Lori-Ann Christie
Trends in Neurosciences, Vol. 30, No. 9. (September 2007), pp. 464-472
Important Roles of Glutathione
Fight against oxidative cell damage (Free Radicals)
• Protein Synthesis
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
• Fight Inflammation
• ATP (energy) production
Our cells are constantly under attack by Free Radicals, which can cause a reduction of our cells ability to function optimally.
Click here for more about Glutathione and its benefits to our body.
Monday, January 21, 2008
Types of Free Radicals
Where do free radicals come from?
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
Types of Free Radicals
The fight against free radicals is often a tricky one. There is not a mythical, ambiguous, or singular form on free radical. Science has confirmed that there are many different types of free radicals including:
• Superoxide
• Hydrogen Peroxide
• Single Oxygen and Hydroxyl Radicals
Important Note: Not all antioxidants can sufficiently match up with all types of free radicals.
The great news about Glutathione is that regardless of the type of free radical, Glutathione has the ability to properly match up and neutralize it, thus increasing cellular protection and function
Click here for more about Glutathione and its benefits to our body.
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
Types of Free Radicals
The fight against free radicals is often a tricky one. There is not a mythical, ambiguous, or singular form on free radical. Science has confirmed that there are many different types of free radicals including:
• Superoxide
• Hydrogen Peroxide
• Single Oxygen and Hydroxyl Radicals
Important Note: Not all antioxidants can sufficiently match up with all types of free radicals.
The great news about Glutathione is that regardless of the type of free radical, Glutathione has the ability to properly match up and neutralize it, thus increasing cellular protection and function
Click here for more about Glutathione and its benefits to our body.
Dr. Robert Keller and Glutathione
Robert Keller MD, MS, FACP, has been named as one of the world’s 2,000 Outstanding Scientists of the 21st Century, and has served on the scientific review panels for the National Institutes of Health and the VA.
The Consumers’ Research Council has named Dr. Keller one of America’s “Top Physicians in 2003, 2004, 2005, 2006, and 2007 in the fields of Internal Medicine, Immunology and Hematology.
Dr. Keller has served on the faculties of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.) He has published more than 100 original articles in various scientific and medical journals and has been awarded several patents.
Dr Keller was elected to The Board of Governors of the American Academy of HIV medicine.
Read Robert H. Keller, MD, MS, FACP, AAHIVS CurriculmVitae
Dr. Robert H. Keller, one of the world’s leading scientists dedicated 10 years of research and development into MaxGXL to assist the world in its quest for a higher quality of health.Out of all the biological processes that Dr Keller could have focused his attention on, he chose to investigate a way to naturally optimize the body’s production of glutathione.
Glutathione is a fairly tricky word, but your body relies on its function every single day.
Important Roles of Glutathione
• Fight against oxidative cell damage (Free Radicals)
• Protein Synthesis
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
• Fight Inflammation
• ATP (energy) production
Our cells are constantly under attack by Free Radicals, which can cause a reduction of our cells ability to function optimally.
Click here for more about Glutathione and its benefits to our body.
The Consumers’ Research Council has named Dr. Keller one of America’s “Top Physicians in 2003, 2004, 2005, 2006, and 2007 in the fields of Internal Medicine, Immunology and Hematology.
Dr. Keller has served on the faculties of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.) He has published more than 100 original articles in various scientific and medical journals and has been awarded several patents.
Dr Keller was elected to The Board of Governors of the American Academy of HIV medicine.
Read Robert H. Keller, MD, MS, FACP, AAHIVS CurriculmVitae
Dr. Robert H. Keller, one of the world’s leading scientists dedicated 10 years of research and development into MaxGXL to assist the world in its quest for a higher quality of health.Out of all the biological processes that Dr Keller could have focused his attention on, he chose to investigate a way to naturally optimize the body’s production of glutathione.
Glutathione is a fairly tricky word, but your body relies on its function every single day.
Important Roles of Glutathione
• Fight against oxidative cell damage (Free Radicals)
• Protein Synthesis
• Amino Acid transport
• Cellular detoxification
• Immune system enhancement
• Enzyme activation
• Fight Inflammation
• ATP (energy) production
Our cells are constantly under attack by Free Radicals, which can cause a reduction of our cells ability to function optimally.
Click here for more about Glutathione and its benefits to our body.
Glutathione - MaxGXL
Supplements Containing Glutathione Alone Will NOT Increase The Body’s GSH Levels!It is pointless to purchase supplements that merely contain glutathione, because the digestive system breaks down ingested glutathione and it will not be absorbed into your system.
MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxify Your Body
MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.
THE MAX GXL is a PATENTED High Performance Formula which:
Dramatically Raises Your Energy Level
Slows Down The Aging Process
Strengthens Your Immune System
Fights Inflammation and Diseases of Aging
Improves Athletic Performance & Recovery
Detoxify Your Body
Glutathione Fact 3
Increasing Age and Other Factors Reduce the Body’s Production and Utilization of GSH.
Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness.
Research shows that GSH levels decline by 8% to 12% per decade, beginning at the age of 20.
Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle.
While you need glutathione for a productive immune system , a weakened immune system hampers the production of glutathione.
Detoxifies your body
Antioxidants are well documented and known to possess vital roles in health maintenance and disease prevention. Glutathione is your cell's own majorAntioxidants. Maintaining elevated glutathione levels aids the body's natural antioxidant function.Biochemical Pharmacology 47: 2113-2123 1994
Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness.
Research shows that GSH levels decline by 8% to 12% per decade, beginning at the age of 20.
Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle.
While you need glutathione for a productive immune system , a weakened immune system hampers the production of glutathione.
Detoxifies your body
Antioxidants are well documented and known to possess vital roles in health maintenance and disease prevention. Glutathione is your cell's own majorAntioxidants. Maintaining elevated glutathione levels aids the body's natural antioxidant function.Biochemical Pharmacology 47: 2113-2123 1994
Glutathione Fact 2 - slow down the aging process
Glutathione has been shown to slow down the aging process, detoxify and improve liver function, strengthen the immune system, and reduce the chances of developing cancer.
Glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.
Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
Glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.
Among the uses that have been reported for glutathione are:
treatment of poisoning, particularly heavy metal poisons
treatment of idiopathic pulmonary firbosis
increasing the effectiveness and reducing the toxicity of cis-platinum, a chemo drug used to treat breast cancer
treating Parkinson's disease
lowering blood pressure in patients with diabetes
increasing male sperm counts in humans and animals
treatment of liver cancer
treatment of sickle cell anemia
Glutathione Fact 1 - produced naturally in our cells
Glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging.
Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine.
In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.
Glutathione's three major roles in the body are summarized by the letters A-B-C.
- Anti-oxidant- Blood Booster- Cell Detoxifier
Glutathione - your body's master antioxidant
Glutathione (GSH) is the most powerful, prevalent antioxidant in your body!
GSH is manufactured by your cells and all you need to do is to provide the raw materials for your body to produce glutathione optimally.
Increasing your glutathione level will naturally increase your energy, detoxify your body and strengthen your immune system.
Dr. Robert Keller
Robert Keller MD, MS, FACP, has been named as one of the world’s 2,000 Outstanding Scientists of the 21st Century, and has served on the scientific review panels for the National Institutes of Health and the Veterans Administration.
MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support. by destroying environmental toxins, thus helping the liver to function as the main production site and storehouse for glutathione. The graph below shows the increase in glutathione levels experienced by 4 groups of patients. Group 1 (normal health patients) were tested after 6 months of use, while Groups 2, 3 and 4 (HIV, Hepatitis C, and Chronic Viral Illness respectively) were tested after only 3 months of the MaxGXL regimen.
Click here for more about Glutathione and its benefits to our body.
GSH is manufactured by your cells and all you need to do is to provide the raw materials for your body to produce glutathione optimally.
Increasing your glutathione level will naturally increase your energy, detoxify your body and strengthen your immune system.
Dr. Robert Keller
Robert Keller MD, MS, FACP, has been named as one of the world’s 2,000 Outstanding Scientists of the 21st Century, and has served on the scientific review panels for the National Institutes of Health and the Veterans Administration.
MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support. by destroying environmental toxins, thus helping the liver to function as the main production site and storehouse for glutathione. The graph below shows the increase in glutathione levels experienced by 4 groups of patients. Group 1 (normal health patients) were tested after 6 months of use, while Groups 2, 3 and 4 (HIV, Hepatitis C, and Chronic Viral Illness respectively) were tested after only 3 months of the MaxGXL regimen.
Click here for more about Glutathione and its benefits to our body.
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